Fetal Mesenchymal Stromal Cells: an Opportunity for Prenatal Cellular Therapy

PURPOSE OF REVIEW: The aim of the study is to provide an overview on the possibility of treating congenital disorders prenatally with mesenchymal stromal cells (MSCs). RECENT FINDINGS: MSCs have multilineage potential and a low immunogenic profile and are immunomodulatory and more easy to expand in...

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Detalles Bibliográficos
Autores principales: Sagar, Rachel, Walther-Jallow, Lilian, David, Anna L., Götherström, Cecilia, Westgren, Magnus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Prenatal Therapies (WH Peranteau, Section Editor)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866262/
https://www.ncbi.nlm.nih.gov/pubmed/29600162
http://dx.doi.org/10.1007/s40778-018-0118-8
Descripción
Sumario:PURPOSE OF REVIEW: The aim of the study is to provide an overview on the possibility of treating congenital disorders prenatally with mesenchymal stromal cells (MSCs). RECENT FINDINGS: MSCs have multilineage potential and a low immunogenic profile and are immunomodulatory and more easy to expand in culture. Their ability to migrate, engraft and differentiate, or act via a paracrine effect on target tissues makes MSCs candidates for clinical therapies. Fetal and extra-fetal MSCs offer higher therapeutic potential compared to MSCs derived from adult sources. SUMMARY: MSCs may be safely transplanted prenatally via ultrasound-guided injection into the umbilical cord. Due to these characteristics, fetal MSCs are of great interest in the field of in utero stem cell transplantation for treatment of congenital disease.

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