Hypercholesterolemia‐Induced Loss of Flow‐Induced Vasodilation and Lesion Formation in Apolipoprotein E–Deficient Mice Critically Depend on Inwardly Rectifying K(+) Channels

BACKGROUND: Hypercholesterolemia‐induced decreased availability of nitric oxide (NO) is a major factor in cardiovascular disease. We previously established that cholesterol suppresses endothelial inwardly rectifying K(+) (Kir) channels and that Kir2.1 is an upstream mediator of flow‐induced NO produ...

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Detalles Bibliográficos
Autores principales: Fancher, Ibra S., Ahn, Sang Joon, Adamos, Crystal, Osborn, Catherine, Oh, Myung‐Jin, Fang, Yun, Reardon, Catherine A., Getz, Godfrey S., Phillips, Shane A., Levitan, Irena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866319/
https://www.ncbi.nlm.nih.gov/pubmed/29502106
http://dx.doi.org/10.1161/JAHA.117.007430

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