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Sex Differences in the Association Between Measures of General and Central Adiposity and the Risk of Myocardial Infarction: Results From the UK Biobank

BACKGROUND: There are substantial differences in the distribution of adipose tissue between women and men. We assessed the sex‐specific relationships and their differences between measures of general and central adiposity and the risk of incident myocardial infarction (MI). METHODS AND RESULTS: Betw...

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Detalles Bibliográficos
Autores principales: Peters, Sanne A. E., Bots, Sophie H., Woodward, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866342/
https://www.ncbi.nlm.nih.gov/pubmed/29490971
http://dx.doi.org/10.1161/JAHA.117.008507
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author Peters, Sanne A. E.
Bots, Sophie H.
Woodward, Mark
author_facet Peters, Sanne A. E.
Bots, Sophie H.
Woodward, Mark
author_sort Peters, Sanne A. E.
collection PubMed
description BACKGROUND: There are substantial differences in the distribution of adipose tissue between women and men. We assessed the sex‐specific relationships and their differences between measures of general and central adiposity and the risk of incident myocardial infarction (MI). METHODS AND RESULTS: Between 2006 and 2010, the UK Biobank recruited over 500 000 participants aged 40 to 69 years across the United Kingdom. During 7 years of follow‐up, 5710 cases of MI (28% women) were recorded among 265 988 women and 213 622 men without a history of cardiovascular disease at baseline. Cox regression models yielded adjusted hazard ratios for MI associated with body mass index, waist circumference, waist‐to‐hip ratio, and waist‐to‐height ratio. There was an approximate log‐linear relationship between measures of general and central adiposity and the risk of MI in both sexes. A 1‐SD higher in body mass index, waist circumference, waist‐to‐hip ratio, and waist‐to‐height ratio, respectively, were associated with hazard ratios (confidence intervals) for MI of 1.22 (1.17; 1.28), 1.35 (1.28; 1.42), 1.49 (1.39; 1.59), and 1.34 (1.27; 1.40) in women and of 1.28 (1.23; 1.32), 1.28 (1.23; 1.33), 1.36 (1.30; 1.43), and 1.33 (1.28; 1.38) in men. The corresponding women‐to‐men ratios of hazard ratios were 0.96 (0.91; 1.02), 1.07 (1.00; 1.14), 1.15 (1.06; 1.24), and 1.03 (0.97; 1.09). CONCLUSIONS: Although general and central adiposity measures each have profound deleterious effects on the risk of MI in both sexes, a higher waist circumference and waist‐to‐hip ratio conferred a greater excess risk of MI in women than in men. Waist‐to‐hip ratio was more strongly associated with the risk of MI than body mass index in both sexes, especially in women.
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spelling pubmed-58663422018-03-28 Sex Differences in the Association Between Measures of General and Central Adiposity and the Risk of Myocardial Infarction: Results From the UK Biobank Peters, Sanne A. E. Bots, Sophie H. Woodward, Mark J Am Heart Assoc Original Research BACKGROUND: There are substantial differences in the distribution of adipose tissue between women and men. We assessed the sex‐specific relationships and their differences between measures of general and central adiposity and the risk of incident myocardial infarction (MI). METHODS AND RESULTS: Between 2006 and 2010, the UK Biobank recruited over 500 000 participants aged 40 to 69 years across the United Kingdom. During 7 years of follow‐up, 5710 cases of MI (28% women) were recorded among 265 988 women and 213 622 men without a history of cardiovascular disease at baseline. Cox regression models yielded adjusted hazard ratios for MI associated with body mass index, waist circumference, waist‐to‐hip ratio, and waist‐to‐height ratio. There was an approximate log‐linear relationship between measures of general and central adiposity and the risk of MI in both sexes. A 1‐SD higher in body mass index, waist circumference, waist‐to‐hip ratio, and waist‐to‐height ratio, respectively, were associated with hazard ratios (confidence intervals) for MI of 1.22 (1.17; 1.28), 1.35 (1.28; 1.42), 1.49 (1.39; 1.59), and 1.34 (1.27; 1.40) in women and of 1.28 (1.23; 1.32), 1.28 (1.23; 1.33), 1.36 (1.30; 1.43), and 1.33 (1.28; 1.38) in men. The corresponding women‐to‐men ratios of hazard ratios were 0.96 (0.91; 1.02), 1.07 (1.00; 1.14), 1.15 (1.06; 1.24), and 1.03 (0.97; 1.09). CONCLUSIONS: Although general and central adiposity measures each have profound deleterious effects on the risk of MI in both sexes, a higher waist circumference and waist‐to‐hip ratio conferred a greater excess risk of MI in women than in men. Waist‐to‐hip ratio was more strongly associated with the risk of MI than body mass index in both sexes, especially in women. John Wiley and Sons Inc. 2018-02-28 /pmc/articles/PMC5866342/ /pubmed/29490971 http://dx.doi.org/10.1161/JAHA.117.008507 Text en © 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Peters, Sanne A. E.
Bots, Sophie H.
Woodward, Mark
Sex Differences in the Association Between Measures of General and Central Adiposity and the Risk of Myocardial Infarction: Results From the UK Biobank
title Sex Differences in the Association Between Measures of General and Central Adiposity and the Risk of Myocardial Infarction: Results From the UK Biobank
title_full Sex Differences in the Association Between Measures of General and Central Adiposity and the Risk of Myocardial Infarction: Results From the UK Biobank
title_fullStr Sex Differences in the Association Between Measures of General and Central Adiposity and the Risk of Myocardial Infarction: Results From the UK Biobank
title_full_unstemmed Sex Differences in the Association Between Measures of General and Central Adiposity and the Risk of Myocardial Infarction: Results From the UK Biobank
title_short Sex Differences in the Association Between Measures of General and Central Adiposity and the Risk of Myocardial Infarction: Results From the UK Biobank
title_sort sex differences in the association between measures of general and central adiposity and the risk of myocardial infarction: results from the uk biobank
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866342/
https://www.ncbi.nlm.nih.gov/pubmed/29490971
http://dx.doi.org/10.1161/JAHA.117.008507
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