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Relationship between heterotopic ossification and traumatic brain injury: Why severe traumatic brain injury increases the risk of heterotopic ossification
Heterotopic ossification (HO) is a pathological phenomenon in which ectopic lamellar bone forms in soft tissues. HO involves many predisposing factors, including congenital and postnatal factors. Postnatal HO is usually induced by fracture, burn, neurological damage (brain injury and spinal cord inj...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Chinese Speaking Orthopaedic Society
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866497/ https://www.ncbi.nlm.nih.gov/pubmed/29662775 http://dx.doi.org/10.1016/j.jot.2017.10.002 |
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author | Huang, Huan Cheng, Wen-Xiang Hu, Yi-Ping Chen, Jian-Hai Zheng, Zheng-Tan Zhang, Peng |
author_facet | Huang, Huan Cheng, Wen-Xiang Hu, Yi-Ping Chen, Jian-Hai Zheng, Zheng-Tan Zhang, Peng |
author_sort | Huang, Huan |
collection | PubMed |
description | Heterotopic ossification (HO) is a pathological phenomenon in which ectopic lamellar bone forms in soft tissues. HO involves many predisposing factors, including congenital and postnatal factors. Postnatal HO is usually induced by fracture, burn, neurological damage (brain injury and spinal cord injury) and joint replacement. Recent studies have found that patients who suffered from bone fracture combined with severe traumatic brain injury (S-TBI) are at a significantly increased risk for HO occurrence. Thus, considerable research focused on the influence of S-TBI on fracture healing and bone formation, as well as on the changes in various osteogenic factors with S-TBI occurrence. Brain damage promotes bone formation, but the exact mechanisms underlying bone formation and HO after S-TBI remain to be clarified. Hence, this article summarises the findings of previous studies on the relationship between S-TBI and HO and discusses the probable causes and mechanisms of HO caused by S-TBI. The translational potential of this article: A better understanding of the probable causes of traumatic brain injury–induced HO can provide new perspectives and ideas in preventing HO and may support to design more targeted therapies to reduce HO or enhance the bone formation. |
format | Online Article Text |
id | pubmed-5866497 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Chinese Speaking Orthopaedic Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-58664972018-04-16 Relationship between heterotopic ossification and traumatic brain injury: Why severe traumatic brain injury increases the risk of heterotopic ossification Huang, Huan Cheng, Wen-Xiang Hu, Yi-Ping Chen, Jian-Hai Zheng, Zheng-Tan Zhang, Peng J Orthop Translat Review Article Heterotopic ossification (HO) is a pathological phenomenon in which ectopic lamellar bone forms in soft tissues. HO involves many predisposing factors, including congenital and postnatal factors. Postnatal HO is usually induced by fracture, burn, neurological damage (brain injury and spinal cord injury) and joint replacement. Recent studies have found that patients who suffered from bone fracture combined with severe traumatic brain injury (S-TBI) are at a significantly increased risk for HO occurrence. Thus, considerable research focused on the influence of S-TBI on fracture healing and bone formation, as well as on the changes in various osteogenic factors with S-TBI occurrence. Brain damage promotes bone formation, but the exact mechanisms underlying bone formation and HO after S-TBI remain to be clarified. Hence, this article summarises the findings of previous studies on the relationship between S-TBI and HO and discusses the probable causes and mechanisms of HO caused by S-TBI. The translational potential of this article: A better understanding of the probable causes of traumatic brain injury–induced HO can provide new perspectives and ideas in preventing HO and may support to design more targeted therapies to reduce HO or enhance the bone formation. Chinese Speaking Orthopaedic Society 2017-11-14 /pmc/articles/PMC5866497/ /pubmed/29662775 http://dx.doi.org/10.1016/j.jot.2017.10.002 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Huang, Huan Cheng, Wen-Xiang Hu, Yi-Ping Chen, Jian-Hai Zheng, Zheng-Tan Zhang, Peng Relationship between heterotopic ossification and traumatic brain injury: Why severe traumatic brain injury increases the risk of heterotopic ossification |
title | Relationship between heterotopic ossification and traumatic brain injury: Why severe traumatic brain injury increases the risk of heterotopic ossification |
title_full | Relationship between heterotopic ossification and traumatic brain injury: Why severe traumatic brain injury increases the risk of heterotopic ossification |
title_fullStr | Relationship between heterotopic ossification and traumatic brain injury: Why severe traumatic brain injury increases the risk of heterotopic ossification |
title_full_unstemmed | Relationship between heterotopic ossification and traumatic brain injury: Why severe traumatic brain injury increases the risk of heterotopic ossification |
title_short | Relationship between heterotopic ossification and traumatic brain injury: Why severe traumatic brain injury increases the risk of heterotopic ossification |
title_sort | relationship between heterotopic ossification and traumatic brain injury: why severe traumatic brain injury increases the risk of heterotopic ossification |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866497/ https://www.ncbi.nlm.nih.gov/pubmed/29662775 http://dx.doi.org/10.1016/j.jot.2017.10.002 |
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