Cargando…

Relationship between heterotopic ossification and traumatic brain injury: Why severe traumatic brain injury increases the risk of heterotopic ossification

Heterotopic ossification (HO) is a pathological phenomenon in which ectopic lamellar bone forms in soft tissues. HO involves many predisposing factors, including congenital and postnatal factors. Postnatal HO is usually induced by fracture, burn, neurological damage (brain injury and spinal cord inj...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Huan, Cheng, Wen-Xiang, Hu, Yi-Ping, Chen, Jian-Hai, Zheng, Zheng-Tan, Zhang, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Speaking Orthopaedic Society 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866497/
https://www.ncbi.nlm.nih.gov/pubmed/29662775
http://dx.doi.org/10.1016/j.jot.2017.10.002
_version_ 1783308840962359296
author Huang, Huan
Cheng, Wen-Xiang
Hu, Yi-Ping
Chen, Jian-Hai
Zheng, Zheng-Tan
Zhang, Peng
author_facet Huang, Huan
Cheng, Wen-Xiang
Hu, Yi-Ping
Chen, Jian-Hai
Zheng, Zheng-Tan
Zhang, Peng
author_sort Huang, Huan
collection PubMed
description Heterotopic ossification (HO) is a pathological phenomenon in which ectopic lamellar bone forms in soft tissues. HO involves many predisposing factors, including congenital and postnatal factors. Postnatal HO is usually induced by fracture, burn, neurological damage (brain injury and spinal cord injury) and joint replacement. Recent studies have found that patients who suffered from bone fracture combined with severe traumatic brain injury (S-TBI) are at a significantly increased risk for HO occurrence. Thus, considerable research focused on the influence of S-TBI on fracture healing and bone formation, as well as on the changes in various osteogenic factors with S-TBI occurrence. Brain damage promotes bone formation, but the exact mechanisms underlying bone formation and HO after S-TBI remain to be clarified. Hence, this article summarises the findings of previous studies on the relationship between S-TBI and HO and discusses the probable causes and mechanisms of HO caused by S-TBI. The translational potential of this article: A better understanding of the probable causes of traumatic brain injury–induced HO can provide new perspectives and ideas in preventing HO and may support to design more targeted therapies to reduce HO or enhance the bone formation.
format Online
Article
Text
id pubmed-5866497
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Chinese Speaking Orthopaedic Society
record_format MEDLINE/PubMed
spelling pubmed-58664972018-04-16 Relationship between heterotopic ossification and traumatic brain injury: Why severe traumatic brain injury increases the risk of heterotopic ossification Huang, Huan Cheng, Wen-Xiang Hu, Yi-Ping Chen, Jian-Hai Zheng, Zheng-Tan Zhang, Peng J Orthop Translat Review Article Heterotopic ossification (HO) is a pathological phenomenon in which ectopic lamellar bone forms in soft tissues. HO involves many predisposing factors, including congenital and postnatal factors. Postnatal HO is usually induced by fracture, burn, neurological damage (brain injury and spinal cord injury) and joint replacement. Recent studies have found that patients who suffered from bone fracture combined with severe traumatic brain injury (S-TBI) are at a significantly increased risk for HO occurrence. Thus, considerable research focused on the influence of S-TBI on fracture healing and bone formation, as well as on the changes in various osteogenic factors with S-TBI occurrence. Brain damage promotes bone formation, but the exact mechanisms underlying bone formation and HO after S-TBI remain to be clarified. Hence, this article summarises the findings of previous studies on the relationship between S-TBI and HO and discusses the probable causes and mechanisms of HO caused by S-TBI. The translational potential of this article: A better understanding of the probable causes of traumatic brain injury–induced HO can provide new perspectives and ideas in preventing HO and may support to design more targeted therapies to reduce HO or enhance the bone formation. Chinese Speaking Orthopaedic Society 2017-11-14 /pmc/articles/PMC5866497/ /pubmed/29662775 http://dx.doi.org/10.1016/j.jot.2017.10.002 Text en © 2017 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Huang, Huan
Cheng, Wen-Xiang
Hu, Yi-Ping
Chen, Jian-Hai
Zheng, Zheng-Tan
Zhang, Peng
Relationship between heterotopic ossification and traumatic brain injury: Why severe traumatic brain injury increases the risk of heterotopic ossification
title Relationship between heterotopic ossification and traumatic brain injury: Why severe traumatic brain injury increases the risk of heterotopic ossification
title_full Relationship between heterotopic ossification and traumatic brain injury: Why severe traumatic brain injury increases the risk of heterotopic ossification
title_fullStr Relationship between heterotopic ossification and traumatic brain injury: Why severe traumatic brain injury increases the risk of heterotopic ossification
title_full_unstemmed Relationship between heterotopic ossification and traumatic brain injury: Why severe traumatic brain injury increases the risk of heterotopic ossification
title_short Relationship between heterotopic ossification and traumatic brain injury: Why severe traumatic brain injury increases the risk of heterotopic ossification
title_sort relationship between heterotopic ossification and traumatic brain injury: why severe traumatic brain injury increases the risk of heterotopic ossification
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866497/
https://www.ncbi.nlm.nih.gov/pubmed/29662775
http://dx.doi.org/10.1016/j.jot.2017.10.002
work_keys_str_mv AT huanghuan relationshipbetweenheterotopicossificationandtraumaticbraininjurywhyseveretraumaticbraininjuryincreasestheriskofheterotopicossification
AT chengwenxiang relationshipbetweenheterotopicossificationandtraumaticbraininjurywhyseveretraumaticbraininjuryincreasestheriskofheterotopicossification
AT huyiping relationshipbetweenheterotopicossificationandtraumaticbraininjurywhyseveretraumaticbraininjuryincreasestheriskofheterotopicossification
AT chenjianhai relationshipbetweenheterotopicossificationandtraumaticbraininjurywhyseveretraumaticbraininjuryincreasestheriskofheterotopicossification
AT zhengzhengtan relationshipbetweenheterotopicossificationandtraumaticbraininjurywhyseveretraumaticbraininjuryincreasestheriskofheterotopicossification
AT zhangpeng relationshipbetweenheterotopicossificationandtraumaticbraininjurywhyseveretraumaticbraininjuryincreasestheriskofheterotopicossification