Transmembrane E3 ligase RNF183 mediates ER stress-induced apoptosis by degrading Bcl-xL

The accumulation of misfolded proteins in the endoplasmic reticulum (ER) causes ER stress and triggers the unfolded protein response (UPR). Failure to resolve ER stress leads to apoptotic cell death via a yet unclear mechanism. Here, we show that RNF183, a membrane-spanning RING finger protein, loca...

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Detalles Bibliográficos
Autores principales: Wu, Yanfang, Li, Xia, Jia, Junying, Zhang, Yanpeng, Li, Jing, Zhu, Zhengmao, Wang, Huaqing, Tang, Jie, Hu, Junjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2018
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866564/
https://www.ncbi.nlm.nih.gov/pubmed/29507230
http://dx.doi.org/10.1073/pnas.1716439115

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