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Gene Duplicates Resolving Sexual Conflict Rapidly Evolved Essential Gametogenesis Functions
Males and females have different fitness optima but share vast majority of their genomes, causing an inherent genetic conflict between the two sexes that must be resolved to achieve maximal population fitness. We show that two tandem duplicate genes found specifically in Drosophila melanogaster are...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866764/ https://www.ncbi.nlm.nih.gov/pubmed/29459709 http://dx.doi.org/10.1038/s41559-018-0471-0 |
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author | VanKuren, Nicholas W. Long, Manyuan |
author_facet | VanKuren, Nicholas W. Long, Manyuan |
author_sort | VanKuren, Nicholas W. |
collection | PubMed |
description | Males and females have different fitness optima but share vast majority of their genomes, causing an inherent genetic conflict between the two sexes that must be resolved to achieve maximal population fitness. We show that two tandem duplicate genes found specifically in Drosophila melanogaster are sexually antagonistic, but rapidly evolved sex-specific functions and expression patterns that mitigate their antagonistic effects. We use copy-specific knockouts and rescue experiments to show that Apollo is essential for male fertility but detrimental to female fertility, in addition to its important role in development, while Artemis is essential for female fertility but detrimental to male fertility. Further analyses show that Apl and Art have essential roles in spermatogenesis and oogenesis. These duplicates formed ~200,000 years ago, underwent a strong selective sweep and lost most expression in the antagonized sex. These data provide direct evidence that gene duplication allowed rapid mitigation of sexual conflict to evolve essential gametogenesis functions. |
format | Online Article Text |
id | pubmed-5866764 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
record_format | MEDLINE/PubMed |
spelling | pubmed-58667642018-08-19 Gene Duplicates Resolving Sexual Conflict Rapidly Evolved Essential Gametogenesis Functions VanKuren, Nicholas W. Long, Manyuan Nat Ecol Evol Article Males and females have different fitness optima but share vast majority of their genomes, causing an inherent genetic conflict between the two sexes that must be resolved to achieve maximal population fitness. We show that two tandem duplicate genes found specifically in Drosophila melanogaster are sexually antagonistic, but rapidly evolved sex-specific functions and expression patterns that mitigate their antagonistic effects. We use copy-specific knockouts and rescue experiments to show that Apollo is essential for male fertility but detrimental to female fertility, in addition to its important role in development, while Artemis is essential for female fertility but detrimental to male fertility. Further analyses show that Apl and Art have essential roles in spermatogenesis and oogenesis. These duplicates formed ~200,000 years ago, underwent a strong selective sweep and lost most expression in the antagonized sex. These data provide direct evidence that gene duplication allowed rapid mitigation of sexual conflict to evolve essential gametogenesis functions. 2018-02-19 2018-04 /pmc/articles/PMC5866764/ /pubmed/29459709 http://dx.doi.org/10.1038/s41559-018-0471-0 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article VanKuren, Nicholas W. Long, Manyuan Gene Duplicates Resolving Sexual Conflict Rapidly Evolved Essential Gametogenesis Functions |
title | Gene Duplicates Resolving Sexual Conflict Rapidly Evolved Essential Gametogenesis Functions |
title_full | Gene Duplicates Resolving Sexual Conflict Rapidly Evolved Essential Gametogenesis Functions |
title_fullStr | Gene Duplicates Resolving Sexual Conflict Rapidly Evolved Essential Gametogenesis Functions |
title_full_unstemmed | Gene Duplicates Resolving Sexual Conflict Rapidly Evolved Essential Gametogenesis Functions |
title_short | Gene Duplicates Resolving Sexual Conflict Rapidly Evolved Essential Gametogenesis Functions |
title_sort | gene duplicates resolving sexual conflict rapidly evolved essential gametogenesis functions |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866764/ https://www.ncbi.nlm.nih.gov/pubmed/29459709 http://dx.doi.org/10.1038/s41559-018-0471-0 |
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