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Clinical and pathophysiological aspects of type 1 autoimmune pancreatitis
In 1995, Yoshida and colleagues proposed the concept of “autoimmune pancreatitis” (AIP), which has recently been recognized as a new pancreatic inflammatory disease. Recent studies have suggested the existence of two subtypes of AIP: type 1, which involves immunoglobulin G4 (IgG4) and is the pancrea...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Japan
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866825/ https://www.ncbi.nlm.nih.gov/pubmed/29460239 http://dx.doi.org/10.1007/s00535-018-1440-8 |
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author | Uchida, Kazushige Okazaki, Kazuichi |
author_facet | Uchida, Kazushige Okazaki, Kazuichi |
author_sort | Uchida, Kazushige |
collection | PubMed |
description | In 1995, Yoshida and colleagues proposed the concept of “autoimmune pancreatitis” (AIP), which has recently been recognized as a new pancreatic inflammatory disease. Recent studies have suggested the existence of two subtypes of AIP: type 1, which involves immunoglobulin G4 (IgG4) and is the pancreatic manifestation of IgG4-related disease (IgG4-RD); and type 2, which is characterized by granulocytic epithelial lesions. Type 2 AIP is thought to be rare in Japan. Type 1 AIP is characterized by increased serum IgG4 concentrations, lymphoplasmacytic infiltrations, storiform fibrosis, and obliterative phlebitis. However, although type 1 AIP has become increasingly recognized, many clinical and basic issues remain to be solved. This review provides an overview of the recent clinical and basic knowledge of type 1 AIP. |
format | Online Article Text |
id | pubmed-5866825 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer Japan |
record_format | MEDLINE/PubMed |
spelling | pubmed-58668252018-03-27 Clinical and pathophysiological aspects of type 1 autoimmune pancreatitis Uchida, Kazushige Okazaki, Kazuichi J Gastroenterol Review In 1995, Yoshida and colleagues proposed the concept of “autoimmune pancreatitis” (AIP), which has recently been recognized as a new pancreatic inflammatory disease. Recent studies have suggested the existence of two subtypes of AIP: type 1, which involves immunoglobulin G4 (IgG4) and is the pancreatic manifestation of IgG4-related disease (IgG4-RD); and type 2, which is characterized by granulocytic epithelial lesions. Type 2 AIP is thought to be rare in Japan. Type 1 AIP is characterized by increased serum IgG4 concentrations, lymphoplasmacytic infiltrations, storiform fibrosis, and obliterative phlebitis. However, although type 1 AIP has become increasingly recognized, many clinical and basic issues remain to be solved. This review provides an overview of the recent clinical and basic knowledge of type 1 AIP. Springer Japan 2018-02-19 2018 /pmc/articles/PMC5866825/ /pubmed/29460239 http://dx.doi.org/10.1007/s00535-018-1440-8 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Review Uchida, Kazushige Okazaki, Kazuichi Clinical and pathophysiological aspects of type 1 autoimmune pancreatitis |
title | Clinical and pathophysiological aspects of type 1 autoimmune pancreatitis |
title_full | Clinical and pathophysiological aspects of type 1 autoimmune pancreatitis |
title_fullStr | Clinical and pathophysiological aspects of type 1 autoimmune pancreatitis |
title_full_unstemmed | Clinical and pathophysiological aspects of type 1 autoimmune pancreatitis |
title_short | Clinical and pathophysiological aspects of type 1 autoimmune pancreatitis |
title_sort | clinical and pathophysiological aspects of type 1 autoimmune pancreatitis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866825/ https://www.ncbi.nlm.nih.gov/pubmed/29460239 http://dx.doi.org/10.1007/s00535-018-1440-8 |
work_keys_str_mv | AT uchidakazushige clinicalandpathophysiologicalaspectsoftype1autoimmunepancreatitis AT okazakikazuichi clinicalandpathophysiologicalaspectsoftype1autoimmunepancreatitis |