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PARP1 protects from benzo[a]pyrene diol epoxide-induced replication stress and mutagenicity

Poly(ADP-ribosyl)ation (PARylation) is a complex and reversible posttranslational modification catalyzed by poly(ADP-ribose)polymerases (PARPs), which orchestrates protein function and subcellular localization. The function of PARP1 in genotoxic stress response upon induction of oxidative DNA lesion...

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Detalles Bibliográficos
Autores principales:	Fischer, Jan M. F., Zubel, Tabea, Jander, Kirsten, Fix, Jelena, Trussina, Irmela R. E. A., Gebhard, Daniel, Bergemann, Jörg, Bürkle, Alexander, Mangerich, Aswin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2017
Materias:	Genotoxicity and Carcinogenicity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866831/ https://www.ncbi.nlm.nih.gov/pubmed/29196784 http://dx.doi.org/10.1007/s00204-017-2115-6

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