Cargando…

Intestinal Immunomodulatory Cells (T Lymphocytes): A Bridge between Gut Microbiota and Diabetes

Diabetes mellitus (DM) is one of the most familiar chronic diseases threatening human health. Recent studies have shown that the development of diabetes is closely related to an imbalance of the gut microbiota. Accordingly, there is increasing interest in how changes in the gut microbiota affect dia...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Qingwei, Gao, Zezheng, Wang, Han, Wu, Haoran, Liu, Yanwen, Yang, Yingying, Han, Lin, Wang, Xinmiao, Zhao, Linhua, Tong, Xiaolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866888/
https://www.ncbi.nlm.nih.gov/pubmed/29713241
http://dx.doi.org/10.1155/2018/9830939
_version_ 1783308891767963648
author Li, Qingwei
Gao, Zezheng
Wang, Han
Wu, Haoran
Liu, Yanwen
Yang, Yingying
Han, Lin
Wang, Xinmiao
Zhao, Linhua
Tong, Xiaolin
author_facet Li, Qingwei
Gao, Zezheng
Wang, Han
Wu, Haoran
Liu, Yanwen
Yang, Yingying
Han, Lin
Wang, Xinmiao
Zhao, Linhua
Tong, Xiaolin
author_sort Li, Qingwei
collection PubMed
description Diabetes mellitus (DM) is one of the most familiar chronic diseases threatening human health. Recent studies have shown that the development of diabetes is closely related to an imbalance of the gut microbiota. Accordingly, there is increasing interest in how changes in the gut microbiota affect diabetes and its underlying mechanisms. Immunomodulatory cells play important roles in maintaining the normal functioning of the human immune system and in maintaining homeostasis. Intestinal immunomodulatory cells (IICs) are located in the intestinal mucosa and are regarded as an intermediary by which the gut microbiota affects physiological and pathological properties. Diabetes can be regulated by IICs, which act as a bridge linking the gut microbiota and DM. Understanding this bridge role of IICs may clarify the mechanisms by which the gut microbiota contributes to DM. Based on recent research, we summarize this process, thereby providing a basis for further studies of diabetes and other similar immune-related diseases.
format Online
Article
Text
id pubmed-5866888
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Hindawi
record_format MEDLINE/PubMed
spelling pubmed-58668882018-04-30 Intestinal Immunomodulatory Cells (T Lymphocytes): A Bridge between Gut Microbiota and Diabetes Li, Qingwei Gao, Zezheng Wang, Han Wu, Haoran Liu, Yanwen Yang, Yingying Han, Lin Wang, Xinmiao Zhao, Linhua Tong, Xiaolin Mediators Inflamm Review Article Diabetes mellitus (DM) is one of the most familiar chronic diseases threatening human health. Recent studies have shown that the development of diabetes is closely related to an imbalance of the gut microbiota. Accordingly, there is increasing interest in how changes in the gut microbiota affect diabetes and its underlying mechanisms. Immunomodulatory cells play important roles in maintaining the normal functioning of the human immune system and in maintaining homeostasis. Intestinal immunomodulatory cells (IICs) are located in the intestinal mucosa and are regarded as an intermediary by which the gut microbiota affects physiological and pathological properties. Diabetes can be regulated by IICs, which act as a bridge linking the gut microbiota and DM. Understanding this bridge role of IICs may clarify the mechanisms by which the gut microbiota contributes to DM. Based on recent research, we summarize this process, thereby providing a basis for further studies of diabetes and other similar immune-related diseases. Hindawi 2018-03-11 /pmc/articles/PMC5866888/ /pubmed/29713241 http://dx.doi.org/10.1155/2018/9830939 Text en Copyright © 2018 Qingwei Li et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Li, Qingwei
Gao, Zezheng
Wang, Han
Wu, Haoran
Liu, Yanwen
Yang, Yingying
Han, Lin
Wang, Xinmiao
Zhao, Linhua
Tong, Xiaolin
Intestinal Immunomodulatory Cells (T Lymphocytes): A Bridge between Gut Microbiota and Diabetes
title Intestinal Immunomodulatory Cells (T Lymphocytes): A Bridge between Gut Microbiota and Diabetes
title_full Intestinal Immunomodulatory Cells (T Lymphocytes): A Bridge between Gut Microbiota and Diabetes
title_fullStr Intestinal Immunomodulatory Cells (T Lymphocytes): A Bridge between Gut Microbiota and Diabetes
title_full_unstemmed Intestinal Immunomodulatory Cells (T Lymphocytes): A Bridge between Gut Microbiota and Diabetes
title_short Intestinal Immunomodulatory Cells (T Lymphocytes): A Bridge between Gut Microbiota and Diabetes
title_sort intestinal immunomodulatory cells (t lymphocytes): a bridge between gut microbiota and diabetes
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866888/
https://www.ncbi.nlm.nih.gov/pubmed/29713241
http://dx.doi.org/10.1155/2018/9830939
work_keys_str_mv AT liqingwei intestinalimmunomodulatorycellstlymphocytesabridgebetweengutmicrobiotaanddiabetes
AT gaozezheng intestinalimmunomodulatorycellstlymphocytesabridgebetweengutmicrobiotaanddiabetes
AT wanghan intestinalimmunomodulatorycellstlymphocytesabridgebetweengutmicrobiotaanddiabetes
AT wuhaoran intestinalimmunomodulatorycellstlymphocytesabridgebetweengutmicrobiotaanddiabetes
AT liuyanwen intestinalimmunomodulatorycellstlymphocytesabridgebetweengutmicrobiotaanddiabetes
AT yangyingying intestinalimmunomodulatorycellstlymphocytesabridgebetweengutmicrobiotaanddiabetes
AT hanlin intestinalimmunomodulatorycellstlymphocytesabridgebetweengutmicrobiotaanddiabetes
AT wangxinmiao intestinalimmunomodulatorycellstlymphocytesabridgebetweengutmicrobiotaanddiabetes
AT zhaolinhua intestinalimmunomodulatorycellstlymphocytesabridgebetweengutmicrobiotaanddiabetes
AT tongxiaolin intestinalimmunomodulatorycellstlymphocytesabridgebetweengutmicrobiotaanddiabetes