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The Role of Fibroblast Growth Factors in Tooth Development and Incisor Renewal
The mineralized tissue of the tooth is composed of enamel, dentin, cementum, and alveolar bone; enamel is a calcified tissue with no living cells that originates from oral ectoderm, while the three other tissues derive from the cranial neural crest. The fibroblast growth factors (FGFs) are critical...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866892/ https://www.ncbi.nlm.nih.gov/pubmed/29713351 http://dx.doi.org/10.1155/2018/7549160 |
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author | Du, Wen Du, Wei Yu, Haiyang |
author_facet | Du, Wen Du, Wei Yu, Haiyang |
author_sort | Du, Wen |
collection | PubMed |
description | The mineralized tissue of the tooth is composed of enamel, dentin, cementum, and alveolar bone; enamel is a calcified tissue with no living cells that originates from oral ectoderm, while the three other tissues derive from the cranial neural crest. The fibroblast growth factors (FGFs) are critical during the tooth development. Accumulating evidence has shown that the formation of dental tissues, that is, enamel, dentin, and supporting alveolar bone, as well as the development and homeostasis of the stem cells in the continuously growing mouse incisor is mediated by multiple FGF family members. This review discusses the role of FGF signaling in these mineralized tissues, trying to separate its different functions and highlighting the crosstalk between FGFs and other signaling pathways. |
format | Online Article Text |
id | pubmed-5866892 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-58668922018-04-30 The Role of Fibroblast Growth Factors in Tooth Development and Incisor Renewal Du, Wen Du, Wei Yu, Haiyang Stem Cells Int Review Article The mineralized tissue of the tooth is composed of enamel, dentin, cementum, and alveolar bone; enamel is a calcified tissue with no living cells that originates from oral ectoderm, while the three other tissues derive from the cranial neural crest. The fibroblast growth factors (FGFs) are critical during the tooth development. Accumulating evidence has shown that the formation of dental tissues, that is, enamel, dentin, and supporting alveolar bone, as well as the development and homeostasis of the stem cells in the continuously growing mouse incisor is mediated by multiple FGF family members. This review discusses the role of FGF signaling in these mineralized tissues, trying to separate its different functions and highlighting the crosstalk between FGFs and other signaling pathways. Hindawi 2018-03-11 /pmc/articles/PMC5866892/ /pubmed/29713351 http://dx.doi.org/10.1155/2018/7549160 Text en Copyright © 2018 Wen Du et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Du, Wen Du, Wei Yu, Haiyang The Role of Fibroblast Growth Factors in Tooth Development and Incisor Renewal |
title | The Role of Fibroblast Growth Factors in Tooth Development and Incisor Renewal |
title_full | The Role of Fibroblast Growth Factors in Tooth Development and Incisor Renewal |
title_fullStr | The Role of Fibroblast Growth Factors in Tooth Development and Incisor Renewal |
title_full_unstemmed | The Role of Fibroblast Growth Factors in Tooth Development and Incisor Renewal |
title_short | The Role of Fibroblast Growth Factors in Tooth Development and Incisor Renewal |
title_sort | role of fibroblast growth factors in tooth development and incisor renewal |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866892/ https://www.ncbi.nlm.nih.gov/pubmed/29713351 http://dx.doi.org/10.1155/2018/7549160 |
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