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Assessment of Liver Function Using Pharmacokinetic Parameters of Gd-EOB-DTPA: Experimental Study in Rat Hepatectomy Model

OBJECTIVES: To determine whether the pharmacokinetic parameters of Gd-EOB-DTPA can identify the difference in liver function in a rat hepatectomy model. METHODS: A total of 56 eight-week-old male Sprague-Dawley rats were divided into the following groups: control group without hepatectomy (n = 16),...

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Autores principales: You, Myung-Won, Kim, Hyoung Jung, Lim, Hyeong-Seok, Kim, So Yeon, Byun, Jae Ho, Kim, Kyung Won, Hwang, Dae Wook, Lee, Young-Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866904/
https://www.ncbi.nlm.nih.gov/pubmed/29713251
http://dx.doi.org/10.1155/2018/6321316
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author You, Myung-Won
Kim, Hyoung Jung
Lim, Hyeong-Seok
Kim, So Yeon
Byun, Jae Ho
Kim, Kyung Won
Hwang, Dae Wook
Lee, Young-Joo
author_facet You, Myung-Won
Kim, Hyoung Jung
Lim, Hyeong-Seok
Kim, So Yeon
Byun, Jae Ho
Kim, Kyung Won
Hwang, Dae Wook
Lee, Young-Joo
author_sort You, Myung-Won
collection PubMed
description OBJECTIVES: To determine whether the pharmacokinetic parameters of Gd-EOB-DTPA can identify the difference in liver function in a rat hepatectomy model. METHODS: A total of 56 eight-week-old male Sprague-Dawley rats were divided into the following groups: control group without hepatectomy (n = 16), 70% hepatectomy group (n = 14), and 90% hepatectomy group (n = 26). On postoperative day 2, Gd-EOB-DTPA (0.1 mmol/kg) was injected intravenously and serial blood samples were obtained. Pharmacokinetic analysis was performed using a noncompartmental method. Statistical analysis was performed using one-way analysis of variance and post hoc pairwise group comparisons. RESULTS: After excluding 6 rats that died unexpectedly, blood samples were obtained from 16, 14, and 20 rats in the control group, 70% hepatectomy group, and 90% hepatectomy group. There was a significant increase in area under the concentration-time curve from time zero to the time of the last measurable concentration between the 70% and 90% hepatectomy group (P < 0.001). The volume of distribution at steady state was significantly decreased between the control and 70% hepatectomy group (P < 0.001). The clearance was significantly different in all pairwise group comparisons (P < 0.001). CONCLUSIONS: The vascular clearance of Gd-EOB-DTPA can identify the difference in liver function in a rat hepatectomy model.
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spelling pubmed-58669042018-04-30 Assessment of Liver Function Using Pharmacokinetic Parameters of Gd-EOB-DTPA: Experimental Study in Rat Hepatectomy Model You, Myung-Won Kim, Hyoung Jung Lim, Hyeong-Seok Kim, So Yeon Byun, Jae Ho Kim, Kyung Won Hwang, Dae Wook Lee, Young-Joo Contrast Media Mol Imaging Research Article OBJECTIVES: To determine whether the pharmacokinetic parameters of Gd-EOB-DTPA can identify the difference in liver function in a rat hepatectomy model. METHODS: A total of 56 eight-week-old male Sprague-Dawley rats were divided into the following groups: control group without hepatectomy (n = 16), 70% hepatectomy group (n = 14), and 90% hepatectomy group (n = 26). On postoperative day 2, Gd-EOB-DTPA (0.1 mmol/kg) was injected intravenously and serial blood samples were obtained. Pharmacokinetic analysis was performed using a noncompartmental method. Statistical analysis was performed using one-way analysis of variance and post hoc pairwise group comparisons. RESULTS: After excluding 6 rats that died unexpectedly, blood samples were obtained from 16, 14, and 20 rats in the control group, 70% hepatectomy group, and 90% hepatectomy group. There was a significant increase in area under the concentration-time curve from time zero to the time of the last measurable concentration between the 70% and 90% hepatectomy group (P < 0.001). The volume of distribution at steady state was significantly decreased between the control and 70% hepatectomy group (P < 0.001). The clearance was significantly different in all pairwise group comparisons (P < 0.001). CONCLUSIONS: The vascular clearance of Gd-EOB-DTPA can identify the difference in liver function in a rat hepatectomy model. Hindawi 2018-03-11 /pmc/articles/PMC5866904/ /pubmed/29713251 http://dx.doi.org/10.1155/2018/6321316 Text en Copyright © 2018 Myung-Won You et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
You, Myung-Won
Kim, Hyoung Jung
Lim, Hyeong-Seok
Kim, So Yeon
Byun, Jae Ho
Kim, Kyung Won
Hwang, Dae Wook
Lee, Young-Joo
Assessment of Liver Function Using Pharmacokinetic Parameters of Gd-EOB-DTPA: Experimental Study in Rat Hepatectomy Model
title Assessment of Liver Function Using Pharmacokinetic Parameters of Gd-EOB-DTPA: Experimental Study in Rat Hepatectomy Model
title_full Assessment of Liver Function Using Pharmacokinetic Parameters of Gd-EOB-DTPA: Experimental Study in Rat Hepatectomy Model
title_fullStr Assessment of Liver Function Using Pharmacokinetic Parameters of Gd-EOB-DTPA: Experimental Study in Rat Hepatectomy Model
title_full_unstemmed Assessment of Liver Function Using Pharmacokinetic Parameters of Gd-EOB-DTPA: Experimental Study in Rat Hepatectomy Model
title_short Assessment of Liver Function Using Pharmacokinetic Parameters of Gd-EOB-DTPA: Experimental Study in Rat Hepatectomy Model
title_sort assessment of liver function using pharmacokinetic parameters of gd-eob-dtpa: experimental study in rat hepatectomy model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866904/
https://www.ncbi.nlm.nih.gov/pubmed/29713251
http://dx.doi.org/10.1155/2018/6321316
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