Concise Review: Is Cardiac Cell Therapy Dead? Embarrassing Trial Outcomes and New Directions for the Future

Stem cell therapy is a promising strategy for tissue regeneration. The therapeutic benefits of cell therapy are mediated by both direct and indirect mechanisms. However, the application of stem cell therapy in the clinic is hampered by several limitations. This concise review provides a brief introd...

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Detalles Bibliográficos
Autores principales: Tang, Jun‐Nan, Cores, Jhon, Huang, Ke, Cui, Xiao‐Lin, Luo, Lan, Zhang, Jin‐Ying, Li, Tao‐Sheng, Qian, Li, Cheng, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Translational Research Articles and Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866934/
https://www.ncbi.nlm.nih.gov/pubmed/29468830
http://dx.doi.org/10.1002/sctm.17-0196
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author Tang, Jun‐Nan
Cores, Jhon
Huang, Ke
Cui, Xiao‐Lin
Luo, Lan
Zhang, Jin‐Ying
Li, Tao‐Sheng
Qian, Li
Cheng, Ke
author_facet Tang, Jun‐Nan
Cores, Jhon
Huang, Ke
Cui, Xiao‐Lin
Luo, Lan
Zhang, Jin‐Ying
Li, Tao‐Sheng
Qian, Li
Cheng, Ke
author_sort Tang, Jun‐Nan
collection PubMed
description Stem cell therapy is a promising strategy for tissue regeneration. The therapeutic benefits of cell therapy are mediated by both direct and indirect mechanisms. However, the application of stem cell therapy in the clinic is hampered by several limitations. This concise review provides a brief introduction into stem cell therapies for ischemic heart disease. It summarizes cell‐based and cell‐free paradigms, their limitations, and the benefits of using them to target disease. stem cells translational medicine 2018;7:354–359
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spelling pubmed-58669342018-03-28 Concise Review: Is Cardiac Cell Therapy Dead? Embarrassing Trial Outcomes and New Directions for the Future Tang, Jun‐Nan Cores, Jhon Huang, Ke Cui, Xiao‐Lin Luo, Lan Zhang, Jin‐Ying Li, Tao‐Sheng Qian, Li Cheng, Ke Stem Cells Transl Med Translational Research Articles and Reviews Stem cell therapy is a promising strategy for tissue regeneration. The therapeutic benefits of cell therapy are mediated by both direct and indirect mechanisms. However, the application of stem cell therapy in the clinic is hampered by several limitations. This concise review provides a brief introduction into stem cell therapies for ischemic heart disease. It summarizes cell‐based and cell‐free paradigms, their limitations, and the benefits of using them to target disease. stem cells translational medicine 2018;7:354–359 John Wiley and Sons Inc. 2018-02-22 /pmc/articles/PMC5866934/ /pubmed/29468830 http://dx.doi.org/10.1002/sctm.17-0196 Text en © 2018 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Translational Research Articles and Reviews
Tang, Jun‐Nan
Cores, Jhon
Huang, Ke
Cui, Xiao‐Lin
Luo, Lan
Zhang, Jin‐Ying
Li, Tao‐Sheng
Qian, Li
Cheng, Ke
Concise Review: Is Cardiac Cell Therapy Dead? Embarrassing Trial Outcomes and New Directions for the Future
title Concise Review: Is Cardiac Cell Therapy Dead? Embarrassing Trial Outcomes and New Directions for the Future
title_full Concise Review: Is Cardiac Cell Therapy Dead? Embarrassing Trial Outcomes and New Directions for the Future
title_fullStr Concise Review: Is Cardiac Cell Therapy Dead? Embarrassing Trial Outcomes and New Directions for the Future
title_full_unstemmed Concise Review: Is Cardiac Cell Therapy Dead? Embarrassing Trial Outcomes and New Directions for the Future
title_short Concise Review: Is Cardiac Cell Therapy Dead? Embarrassing Trial Outcomes and New Directions for the Future
title_sort concise review: is cardiac cell therapy dead? embarrassing trial outcomes and new directions for the future
topic Translational Research Articles and Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866934/
https://www.ncbi.nlm.nih.gov/pubmed/29468830
http://dx.doi.org/10.1002/sctm.17-0196
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