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Kidney‐Derived c‐Kit(+) Cells Possess Regenerative Potential
Kidney‐derived c‐Kit(+) cells exhibit progenitor/stem cell properties in vitro (self‐renewal capacity, clonogenicity, and multipotentiality). These cells can regenerate epithelial tubular cells following ischemia‐reperfusion injury and accelerate foot processes effacement reversal in a model of acut...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866938/ https://www.ncbi.nlm.nih.gov/pubmed/29575816 http://dx.doi.org/10.1002/sctm.17-0232 |
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author | Gomes, Samirah A. Hare, Joshua M. Rangel, Erika B. |
author_facet | Gomes, Samirah A. Hare, Joshua M. Rangel, Erika B. |
author_sort | Gomes, Samirah A. |
collection | PubMed |
description | Kidney‐derived c‐Kit(+) cells exhibit progenitor/stem cell properties in vitro (self‐renewal capacity, clonogenicity, and multipotentiality). These cells can regenerate epithelial tubular cells following ischemia‐reperfusion injury and accelerate foot processes effacement reversal in a model of acute proteinuria in rats. Several mechanisms are involved in kidney regeneration by kidney‐derived c‐Kit(+) cells, including cell engraftment and differentiation into renal‐like structures, such as tubules, vessels, and podocytes. Moreover, paracrine mechanisms could also account for kidney regeneration, either by stimulating proliferation of surviving cells or modulating autophagy and podocyte cytoskeleton rearrangement through mTOR‐Raptor and ‐Rictor signaling, which ultimately lead to morphological and functional improvement. To gain insights into the functional properties of c‐Kit(+) cells during kidney development, homeostasis, and disease, studies on lineage tracing using transgenic mice will unveil their fate. The results obtained from these studies will set the basis for establishing further investigation on the therapeutic potential of c‐Kit(+) cells for treatment of kidney disease in preclinical and clinical studies. stem cells translational medicine 2018;7:317–324 |
format | Online Article Text |
id | pubmed-5866938 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-58669382018-03-28 Kidney‐Derived c‐Kit(+) Cells Possess Regenerative Potential Gomes, Samirah A. Hare, Joshua M. Rangel, Erika B. Stem Cells Transl Med Perspectives Kidney‐derived c‐Kit(+) cells exhibit progenitor/stem cell properties in vitro (self‐renewal capacity, clonogenicity, and multipotentiality). These cells can regenerate epithelial tubular cells following ischemia‐reperfusion injury and accelerate foot processes effacement reversal in a model of acute proteinuria in rats. Several mechanisms are involved in kidney regeneration by kidney‐derived c‐Kit(+) cells, including cell engraftment and differentiation into renal‐like structures, such as tubules, vessels, and podocytes. Moreover, paracrine mechanisms could also account for kidney regeneration, either by stimulating proliferation of surviving cells or modulating autophagy and podocyte cytoskeleton rearrangement through mTOR‐Raptor and ‐Rictor signaling, which ultimately lead to morphological and functional improvement. To gain insights into the functional properties of c‐Kit(+) cells during kidney development, homeostasis, and disease, studies on lineage tracing using transgenic mice will unveil their fate. The results obtained from these studies will set the basis for establishing further investigation on the therapeutic potential of c‐Kit(+) cells for treatment of kidney disease in preclinical and clinical studies. stem cells translational medicine 2018;7:317–324 John Wiley and Sons Inc. 2018-03-25 /pmc/articles/PMC5866938/ /pubmed/29575816 http://dx.doi.org/10.1002/sctm.17-0232 Text en © 2018 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Perspectives Gomes, Samirah A. Hare, Joshua M. Rangel, Erika B. Kidney‐Derived c‐Kit(+) Cells Possess Regenerative Potential |
title | Kidney‐Derived c‐Kit(+) Cells Possess Regenerative Potential |
title_full | Kidney‐Derived c‐Kit(+) Cells Possess Regenerative Potential |
title_fullStr | Kidney‐Derived c‐Kit(+) Cells Possess Regenerative Potential |
title_full_unstemmed | Kidney‐Derived c‐Kit(+) Cells Possess Regenerative Potential |
title_short | Kidney‐Derived c‐Kit(+) Cells Possess Regenerative Potential |
title_sort | kidney‐derived c‐kit(+) cells possess regenerative potential |
topic | Perspectives |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5866938/ https://www.ncbi.nlm.nih.gov/pubmed/29575816 http://dx.doi.org/10.1002/sctm.17-0232 |
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