Cargando…

Human expression patterns: qualitative and quantitative analysis of thrombospondin‐1 under physiological and pathological conditions

Thrombospondin‐1 (TSP‐1), a matricellular protein and one of the first endogenous anti‐angiogenic molecules identified, has long been considered a potent modulator of human diseases. While the therapeutic effect of TSP‐1 to suppress cancer was investigated in both research and clinical settings, the...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhao, Chen, Isenberg, Jeffrey S., Popel, Aleksander S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867078/
https://www.ncbi.nlm.nih.gov/pubmed/29441713
http://dx.doi.org/10.1111/jcmm.13565
_version_ 1783308923664596992
author Zhao, Chen
Isenberg, Jeffrey S.
Popel, Aleksander S.
author_facet Zhao, Chen
Isenberg, Jeffrey S.
Popel, Aleksander S.
author_sort Zhao, Chen
collection PubMed
description Thrombospondin‐1 (TSP‐1), a matricellular protein and one of the first endogenous anti‐angiogenic molecules identified, has long been considered a potent modulator of human diseases. While the therapeutic effect of TSP‐1 to suppress cancer was investigated in both research and clinical settings, the mechanisms of how TSP‐1 is regulated in cancer remain elusive, and the scientific answers to the question of whether TSP‐1 expressions can be utilized as diagnostic or prognostic marker for patients with cancer are largely inconsistent. Moreover, TSP‐1 plays crucial functions in angiogenesis, inflammation and tissue remodelling, which are essential biological processes in the progression of many cardiovascular diseases, and therefore, its dysregulated expressions in such conditions may have therapeutic significance. Herein, we critically analysed the literature pertaining to TSP‐1 expression in circulating blood and pathological tissues in various types of cancer as well as cardiovascular and inflammation‐related diseases in humans. We compare the secretion rates of TSP‐1 by different cancer and non‐cancer cells and discuss the potential connection between the expression changes of TSP‐1 and vascular endothelial growth factor (VEGF) observed in patients with cancer. Moreover, the pattern and emerging significance of TSP‐1 profiles in cardiovascular disease, such as peripheral arterial disease, diabetes and other related non‐cancer disorders, are highlighted. The analysis of published TSP‐1 data presented in this review may have implications for the future exploration of novel TSP‐1‐based treatment strategies for cancer and cardiovascular‐related diseases.
format Online
Article
Text
id pubmed-5867078
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-58670782018-04-01 Human expression patterns: qualitative and quantitative analysis of thrombospondin‐1 under physiological and pathological conditions Zhao, Chen Isenberg, Jeffrey S. Popel, Aleksander S. J Cell Mol Med Reviews Thrombospondin‐1 (TSP‐1), a matricellular protein and one of the first endogenous anti‐angiogenic molecules identified, has long been considered a potent modulator of human diseases. While the therapeutic effect of TSP‐1 to suppress cancer was investigated in both research and clinical settings, the mechanisms of how TSP‐1 is regulated in cancer remain elusive, and the scientific answers to the question of whether TSP‐1 expressions can be utilized as diagnostic or prognostic marker for patients with cancer are largely inconsistent. Moreover, TSP‐1 plays crucial functions in angiogenesis, inflammation and tissue remodelling, which are essential biological processes in the progression of many cardiovascular diseases, and therefore, its dysregulated expressions in such conditions may have therapeutic significance. Herein, we critically analysed the literature pertaining to TSP‐1 expression in circulating blood and pathological tissues in various types of cancer as well as cardiovascular and inflammation‐related diseases in humans. We compare the secretion rates of TSP‐1 by different cancer and non‐cancer cells and discuss the potential connection between the expression changes of TSP‐1 and vascular endothelial growth factor (VEGF) observed in patients with cancer. Moreover, the pattern and emerging significance of TSP‐1 profiles in cardiovascular disease, such as peripheral arterial disease, diabetes and other related non‐cancer disorders, are highlighted. The analysis of published TSP‐1 data presented in this review may have implications for the future exploration of novel TSP‐1‐based treatment strategies for cancer and cardiovascular‐related diseases. John Wiley and Sons Inc. 2018-02-14 2018-04 /pmc/articles/PMC5867078/ /pubmed/29441713 http://dx.doi.org/10.1111/jcmm.13565 Text en © 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Zhao, Chen
Isenberg, Jeffrey S.
Popel, Aleksander S.
Human expression patterns: qualitative and quantitative analysis of thrombospondin‐1 under physiological and pathological conditions
title Human expression patterns: qualitative and quantitative analysis of thrombospondin‐1 under physiological and pathological conditions
title_full Human expression patterns: qualitative and quantitative analysis of thrombospondin‐1 under physiological and pathological conditions
title_fullStr Human expression patterns: qualitative and quantitative analysis of thrombospondin‐1 under physiological and pathological conditions
title_full_unstemmed Human expression patterns: qualitative and quantitative analysis of thrombospondin‐1 under physiological and pathological conditions
title_short Human expression patterns: qualitative and quantitative analysis of thrombospondin‐1 under physiological and pathological conditions
title_sort human expression patterns: qualitative and quantitative analysis of thrombospondin‐1 under physiological and pathological conditions
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867078/
https://www.ncbi.nlm.nih.gov/pubmed/29441713
http://dx.doi.org/10.1111/jcmm.13565
work_keys_str_mv AT zhaochen humanexpressionpatternsqualitativeandquantitativeanalysisofthrombospondin1underphysiologicalandpathologicalconditions
AT isenbergjeffreys humanexpressionpatternsqualitativeandquantitativeanalysisofthrombospondin1underphysiologicalandpathologicalconditions
AT popelaleksanders humanexpressionpatternsqualitativeandquantitativeanalysisofthrombospondin1underphysiologicalandpathologicalconditions