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Crosstalk between long non‐coding RNAs and Wnt/β‐catenin signalling in cancer

Long non‐coding RNAs (lncRNAs) are non‐protein‐coding transcripts in the human genome which perform crucial functions in diverse biological processes. The abnormal expression of some lncRNAs has been found in tumorigenesis, development and therapy resistance of cancers. They may act as oncogenes or...

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Autores principales: Yang, Gang, Shen, Tianyi, Yi, Xiaoming, Zhang, Zhengyu, Tang, Chaopeng, Wang, Longxin, Zhou, Yulin, Zhou, Wenquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867104/
https://www.ncbi.nlm.nih.gov/pubmed/29392884
http://dx.doi.org/10.1111/jcmm.13522
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author Yang, Gang
Shen, Tianyi
Yi, Xiaoming
Zhang, Zhengyu
Tang, Chaopeng
Wang, Longxin
Zhou, Yulin
Zhou, Wenquan
author_facet Yang, Gang
Shen, Tianyi
Yi, Xiaoming
Zhang, Zhengyu
Tang, Chaopeng
Wang, Longxin
Zhou, Yulin
Zhou, Wenquan
author_sort Yang, Gang
collection PubMed
description Long non‐coding RNAs (lncRNAs) are non‐protein‐coding transcripts in the human genome which perform crucial functions in diverse biological processes. The abnormal expression of some lncRNAs has been found in tumorigenesis, development and therapy resistance of cancers. They may act as oncogenes or tumour suppressors and can be used as diagnostic or prognostic markers, prompting their therapeutic potentials in cancer treatments. Studies have indicated that many lncRNAs are involved in the regulation of several signal pathways, including Wnt/β‐catenin signalling pathway, which has been reported to play a significant role in regulating embryogenesis, cell proliferation and controlling tumour biology. Emerging evidences have suggested that lncRNAs can interact with several components of the Wnt/β‐catenin signalling pathway to regulate the expression of Wnt target genes in cancer. Moreover, the expression of lncRNAs can also be influenced by the pathway. Nevertheless, Wnt/β‐catenin signalling pathway‐related lncRNAs and their interactions in cancer are not systematically analysed before. Considering these, this review emphasized the associations between lncRNAs and Wnt/β‐catenin signalling pathway in cancer initiation, progression and their therapeutic influence. We also provided an overview on characteristics of lncRNAs and Wnt/β‐catenin signalling pathway and discussed their functions in tumour biology. Finally, targeting lncRNAs or/and molecules associated with the Wnt/β‐catenin signalling pathway may be a feasible therapeutic method in the future.
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spelling pubmed-58671042018-04-01 Crosstalk between long non‐coding RNAs and Wnt/β‐catenin signalling in cancer Yang, Gang Shen, Tianyi Yi, Xiaoming Zhang, Zhengyu Tang, Chaopeng Wang, Longxin Zhou, Yulin Zhou, Wenquan J Cell Mol Med Reviews Long non‐coding RNAs (lncRNAs) are non‐protein‐coding transcripts in the human genome which perform crucial functions in diverse biological processes. The abnormal expression of some lncRNAs has been found in tumorigenesis, development and therapy resistance of cancers. They may act as oncogenes or tumour suppressors and can be used as diagnostic or prognostic markers, prompting their therapeutic potentials in cancer treatments. Studies have indicated that many lncRNAs are involved in the regulation of several signal pathways, including Wnt/β‐catenin signalling pathway, which has been reported to play a significant role in regulating embryogenesis, cell proliferation and controlling tumour biology. Emerging evidences have suggested that lncRNAs can interact with several components of the Wnt/β‐catenin signalling pathway to regulate the expression of Wnt target genes in cancer. Moreover, the expression of lncRNAs can also be influenced by the pathway. Nevertheless, Wnt/β‐catenin signalling pathway‐related lncRNAs and their interactions in cancer are not systematically analysed before. Considering these, this review emphasized the associations between lncRNAs and Wnt/β‐catenin signalling pathway in cancer initiation, progression and their therapeutic influence. We also provided an overview on characteristics of lncRNAs and Wnt/β‐catenin signalling pathway and discussed their functions in tumour biology. Finally, targeting lncRNAs or/and molecules associated with the Wnt/β‐catenin signalling pathway may be a feasible therapeutic method in the future. John Wiley and Sons Inc. 2018-02-01 2018-04 /pmc/articles/PMC5867104/ /pubmed/29392884 http://dx.doi.org/10.1111/jcmm.13522 Text en © 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Yang, Gang
Shen, Tianyi
Yi, Xiaoming
Zhang, Zhengyu
Tang, Chaopeng
Wang, Longxin
Zhou, Yulin
Zhou, Wenquan
Crosstalk between long non‐coding RNAs and Wnt/β‐catenin signalling in cancer
title Crosstalk between long non‐coding RNAs and Wnt/β‐catenin signalling in cancer
title_full Crosstalk between long non‐coding RNAs and Wnt/β‐catenin signalling in cancer
title_fullStr Crosstalk between long non‐coding RNAs and Wnt/β‐catenin signalling in cancer
title_full_unstemmed Crosstalk between long non‐coding RNAs and Wnt/β‐catenin signalling in cancer
title_short Crosstalk between long non‐coding RNAs and Wnt/β‐catenin signalling in cancer
title_sort crosstalk between long non‐coding rnas and wnt/β‐catenin signalling in cancer
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867104/
https://www.ncbi.nlm.nih.gov/pubmed/29392884
http://dx.doi.org/10.1111/jcmm.13522
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