Organelle Transplantation: Polymer Functionalization of Isolated Mitochondria for Cellular Transplantation and Metabolic Phenotype Alteration (Adv. Sci. 3/2018)

Isolated mitochondria are polymerically functionalized for transplantation into metabolically compromised cells. In article number 1700530, Elvin Blanco, Dale J. Hamilton, and co‐workers demonstrate that coating mitochondria with a dextran‐triphenylphosphonium (TPP) conjugate results in longer funct...

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Autores principales: Wu, Suhong, Zhang, Aijun, Li, Shumin, Chatterjee, Somik, Qi, Ruogu, Segura‐Ibarra, Victor, Ferrari, Mauro, Gupte, Anisha, Blanco, Elvin, Hamilton, Dale J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Frontispiece
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867122/
http://dx.doi.org/10.1002/advs.201870017
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author Wu, Suhong
Zhang, Aijun
Li, Shumin
Chatterjee, Somik
Qi, Ruogu
Segura‐Ibarra, Victor
Ferrari, Mauro
Gupte, Anisha
Blanco, Elvin
Hamilton, Dale J.
author_facet Wu, Suhong
Zhang, Aijun
Li, Shumin
Chatterjee, Somik
Qi, Ruogu
Segura‐Ibarra, Victor
Ferrari, Mauro
Gupte, Anisha
Blanco, Elvin
Hamilton, Dale J.
author_sort Wu, Suhong
collection PubMed
description Isolated mitochondria are polymerically functionalized for transplantation into metabolically compromised cells. In article number 1700530, Elvin Blanco, Dale J. Hamilton, and co‐workers demonstrate that coating mitochondria with a dextran‐triphenylphosphonium (TPP) conjugate results in longer functional survival of the organelle ex vivo, increased cellular uptake, and an enhanced shift in the metabolic phenotype of cells compared to uncoated mitochondria. [Image: see text]
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spelling pubmed-58671222018-03-28 Organelle Transplantation: Polymer Functionalization of Isolated Mitochondria for Cellular Transplantation and Metabolic Phenotype Alteration (Adv. Sci. 3/2018) Wu, Suhong Zhang, Aijun Li, Shumin Chatterjee, Somik Qi, Ruogu Segura‐Ibarra, Victor Ferrari, Mauro Gupte, Anisha Blanco, Elvin Hamilton, Dale J. Adv Sci (Weinh) Frontispiece Isolated mitochondria are polymerically functionalized for transplantation into metabolically compromised cells. In article number 1700530, Elvin Blanco, Dale J. Hamilton, and co‐workers demonstrate that coating mitochondria with a dextran‐triphenylphosphonium (TPP) conjugate results in longer functional survival of the organelle ex vivo, increased cellular uptake, and an enhanced shift in the metabolic phenotype of cells compared to uncoated mitochondria. [Image: see text] John Wiley and Sons Inc. 2018-03-25 /pmc/articles/PMC5867122/ http://dx.doi.org/10.1002/advs.201870017 Text en © 2018 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial (http://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Frontispiece
Wu, Suhong
Zhang, Aijun
Li, Shumin
Chatterjee, Somik
Qi, Ruogu
Segura‐Ibarra, Victor
Ferrari, Mauro
Gupte, Anisha
Blanco, Elvin
Hamilton, Dale J.
Organelle Transplantation: Polymer Functionalization of Isolated Mitochondria for Cellular Transplantation and Metabolic Phenotype Alteration (Adv. Sci. 3/2018)
title Organelle Transplantation: Polymer Functionalization of Isolated Mitochondria for Cellular Transplantation and Metabolic Phenotype Alteration (Adv. Sci. 3/2018)
title_full Organelle Transplantation: Polymer Functionalization of Isolated Mitochondria for Cellular Transplantation and Metabolic Phenotype Alteration (Adv. Sci. 3/2018)
title_fullStr Organelle Transplantation: Polymer Functionalization of Isolated Mitochondria for Cellular Transplantation and Metabolic Phenotype Alteration (Adv. Sci. 3/2018)
title_full_unstemmed Organelle Transplantation: Polymer Functionalization of Isolated Mitochondria for Cellular Transplantation and Metabolic Phenotype Alteration (Adv. Sci. 3/2018)
title_short Organelle Transplantation: Polymer Functionalization of Isolated Mitochondria for Cellular Transplantation and Metabolic Phenotype Alteration (Adv. Sci. 3/2018)
title_sort organelle transplantation: polymer functionalization of isolated mitochondria for cellular transplantation and metabolic phenotype alteration (adv. sci. 3/2018)
topic Frontispiece
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867122/
http://dx.doi.org/10.1002/advs.201870017
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