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Catalpol Inhibits Amyloid-β Generation Through Promoting α-Cleavage of APP in Swedish Mutant APP Overexpressed N2a Cells

Amyloid-β (Aβ) peptides play a crucial role in the pathogenesis of Alzheimer’s disease (AD), due to its neurotoxicity. Thus, blocking Aβ generation and aggregation in the brain has been realized as an efficient way for the prevention of AD. The natural product catalpol, isolated from Rehmannia gluti...

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Detalles Bibliográficos
Autores principales:	Wang, Zhuo, Huang, Xueshi, Zhao, Pu, Zhao, Limei, Wang, Zhan-You
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867310/ https://www.ncbi.nlm.nih.gov/pubmed/29615891 http://dx.doi.org/10.3389/fnagi.2018.00066

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