Cargando…
Once Daily High Dose Tigecycline Is Optimal: Tigecycline PK/PD Parameters Predict Clinical Effectiveness
Objective: The clinical effectiveness of tigecycline depends on appropriate use, and PK/PD (pharmacokinetic/pharmacodynamic) parameters related to dose and dosing interval. Methods: In our 600-bed university-affiliated teaching hospital, we conducted a tigecycline efficacy review over a three-month...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867575/ https://www.ncbi.nlm.nih.gov/pubmed/29522431 http://dx.doi.org/10.3390/jcm7030049 |
_version_ | 1783308990630854656 |
---|---|
author | Baron, Jeffrey Cai, Shuntao Klein, Natalie Cunha, Burke A. |
author_facet | Baron, Jeffrey Cai, Shuntao Klein, Natalie Cunha, Burke A. |
author_sort | Baron, Jeffrey |
collection | PubMed |
description | Objective: The clinical effectiveness of tigecycline depends on appropriate use, and PK/PD (pharmacokinetic/pharmacodynamic) parameters related to dose and dosing interval. Methods: In our 600-bed university-affiliated teaching hospital, we conducted a tigecycline efficacy review over a three-month period in 34 evaluable patients. Parameters assessed included clinical response, cure or treatment failure, once daily as q12h dosing, maintenance dosing, high dose vs. standard loading regimens, adverse effects, and the effect of infectious disease consultation on outcomes. Results: We found once daily high dose tigecycline (HDT) was highly effective in treating serious systemic infections due to MDR Gram-positive/negative pathogens as well as C. difficile colitis. Adverse effects were infrequent and limited to mild nausea/vomiting. Once daily HDT was highly effective, and the few treatment failures were related to suboptimal/split dosing regimens. Conclusion: Once daily HDT was highly effective when used to treat susceptible pathogens and when optimally dosed, i.e., 200–400 mg (IV) loading dose ×1, followed by a once daily maintenance dose of 100–200 mg (IV) q24h. |
format | Online Article Text |
id | pubmed-5867575 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-58675752018-04-09 Once Daily High Dose Tigecycline Is Optimal: Tigecycline PK/PD Parameters Predict Clinical Effectiveness Baron, Jeffrey Cai, Shuntao Klein, Natalie Cunha, Burke A. J Clin Med Case Report Objective: The clinical effectiveness of tigecycline depends on appropriate use, and PK/PD (pharmacokinetic/pharmacodynamic) parameters related to dose and dosing interval. Methods: In our 600-bed university-affiliated teaching hospital, we conducted a tigecycline efficacy review over a three-month period in 34 evaluable patients. Parameters assessed included clinical response, cure or treatment failure, once daily as q12h dosing, maintenance dosing, high dose vs. standard loading regimens, adverse effects, and the effect of infectious disease consultation on outcomes. Results: We found once daily high dose tigecycline (HDT) was highly effective in treating serious systemic infections due to MDR Gram-positive/negative pathogens as well as C. difficile colitis. Adverse effects were infrequent and limited to mild nausea/vomiting. Once daily HDT was highly effective, and the few treatment failures were related to suboptimal/split dosing regimens. Conclusion: Once daily HDT was highly effective when used to treat susceptible pathogens and when optimally dosed, i.e., 200–400 mg (IV) loading dose ×1, followed by a once daily maintenance dose of 100–200 mg (IV) q24h. MDPI 2018-03-09 /pmc/articles/PMC5867575/ /pubmed/29522431 http://dx.doi.org/10.3390/jcm7030049 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Baron, Jeffrey Cai, Shuntao Klein, Natalie Cunha, Burke A. Once Daily High Dose Tigecycline Is Optimal: Tigecycline PK/PD Parameters Predict Clinical Effectiveness |
title | Once Daily High Dose Tigecycline Is Optimal: Tigecycline PK/PD Parameters Predict Clinical Effectiveness |
title_full | Once Daily High Dose Tigecycline Is Optimal: Tigecycline PK/PD Parameters Predict Clinical Effectiveness |
title_fullStr | Once Daily High Dose Tigecycline Is Optimal: Tigecycline PK/PD Parameters Predict Clinical Effectiveness |
title_full_unstemmed | Once Daily High Dose Tigecycline Is Optimal: Tigecycline PK/PD Parameters Predict Clinical Effectiveness |
title_short | Once Daily High Dose Tigecycline Is Optimal: Tigecycline PK/PD Parameters Predict Clinical Effectiveness |
title_sort | once daily high dose tigecycline is optimal: tigecycline pk/pd parameters predict clinical effectiveness |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867575/ https://www.ncbi.nlm.nih.gov/pubmed/29522431 http://dx.doi.org/10.3390/jcm7030049 |
work_keys_str_mv | AT baronjeffrey oncedailyhighdosetigecyclineisoptimaltigecyclinepkpdparameterspredictclinicaleffectiveness AT caishuntao oncedailyhighdosetigecyclineisoptimaltigecyclinepkpdparameterspredictclinicaleffectiveness AT kleinnatalie oncedailyhighdosetigecyclineisoptimaltigecyclinepkpdparameterspredictclinicaleffectiveness AT cunhaburkea oncedailyhighdosetigecyclineisoptimaltigecyclinepkpdparameterspredictclinicaleffectiveness |