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Associations of Del 301-303 alpha2B-adrenoceptor gene polymorphism with central hemodynamic parameters in the northern Russian population

The ADRA2B gene 301–303 I/D polymorphism is associated with various cardiovascular phenotypes. However, an association of genotypes with the timing structure of cardiac cycle remains unclear. The central hemodynamic parameters were assessed by pulse wave analysis in 63 residents of the Kola Peninsul...

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Autores principales: Melnikov, Vladimir N., Baranov, Victor I., Suvorova, Irina Yu., Krivoschekov, Sergey G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867614/
https://www.ncbi.nlm.nih.gov/pubmed/29212846
http://dx.doi.org/10.1152/physiolgenomics.00071.2017
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author Melnikov, Vladimir N.
Baranov, Victor I.
Suvorova, Irina Yu.
Krivoschekov, Sergey G.
author_facet Melnikov, Vladimir N.
Baranov, Victor I.
Suvorova, Irina Yu.
Krivoschekov, Sergey G.
author_sort Melnikov, Vladimir N.
collection PubMed
description The ADRA2B gene 301–303 I/D polymorphism is associated with various cardiovascular phenotypes. However, an association of genotypes with the timing structure of cardiac cycle remains unclear. The central hemodynamic parameters were assessed by pulse wave analysis in 63 residents of the Kola Peninsula (68 N) aged 27–65 yr. The genotypes were determined by PCR. The paired comparisons revealed that II genotype carriers had higher values of augmentation index (P = 0.014), ejection duration (P = 0.045), and lower SEVR (P = 0.035) than DD homozygotes. Multiple regression analysis adjusted for age, body mass index, heart rate, and blood pressure confirmed these results. Further sex stratified analysis showed that the associations existed only in men (n = 33) whereas in women (n = 30) the differences were suggestive (P < 0.1). It is concluded that in a northern Russian population men carrying I allele have stiffer arteries, shorter diastole duration, and impaired coronary perfusion and seem to be at higher risk for cardiovascular diseases than DD carriers.
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spelling pubmed-58676142018-03-27 Associations of Del 301-303 alpha2B-adrenoceptor gene polymorphism with central hemodynamic parameters in the northern Russian population Melnikov, Vladimir N. Baranov, Victor I. Suvorova, Irina Yu. Krivoschekov, Sergey G. Physiol Genomics PG SNPs The ADRA2B gene 301–303 I/D polymorphism is associated with various cardiovascular phenotypes. However, an association of genotypes with the timing structure of cardiac cycle remains unclear. The central hemodynamic parameters were assessed by pulse wave analysis in 63 residents of the Kola Peninsula (68 N) aged 27–65 yr. The genotypes were determined by PCR. The paired comparisons revealed that II genotype carriers had higher values of augmentation index (P = 0.014), ejection duration (P = 0.045), and lower SEVR (P = 0.035) than DD homozygotes. Multiple regression analysis adjusted for age, body mass index, heart rate, and blood pressure confirmed these results. Further sex stratified analysis showed that the associations existed only in men (n = 33) whereas in women (n = 30) the differences were suggestive (P < 0.1). It is concluded that in a northern Russian population men carrying I allele have stiffer arteries, shorter diastole duration, and impaired coronary perfusion and seem to be at higher risk for cardiovascular diseases than DD carriers. American Physiological Society 2018-02-01 2017-12-06 /pmc/articles/PMC5867614/ /pubmed/29212846 http://dx.doi.org/10.1152/physiolgenomics.00071.2017 Text en Copyright © 2018 the American Physiological Society http://creativecommons.org/licenses/by/4.0/deed.en_US Licensed under Creative Commons Attribution CC-BY 4.0 (http://creativecommons.org/licenses/by/4.0/deed.en_US) : © the American Physiological Society.
spellingShingle PG SNPs
Melnikov, Vladimir N.
Baranov, Victor I.
Suvorova, Irina Yu.
Krivoschekov, Sergey G.
Associations of Del 301-303 alpha2B-adrenoceptor gene polymorphism with central hemodynamic parameters in the northern Russian population
title Associations of Del 301-303 alpha2B-adrenoceptor gene polymorphism with central hemodynamic parameters in the northern Russian population
title_full Associations of Del 301-303 alpha2B-adrenoceptor gene polymorphism with central hemodynamic parameters in the northern Russian population
title_fullStr Associations of Del 301-303 alpha2B-adrenoceptor gene polymorphism with central hemodynamic parameters in the northern Russian population
title_full_unstemmed Associations of Del 301-303 alpha2B-adrenoceptor gene polymorphism with central hemodynamic parameters in the northern Russian population
title_short Associations of Del 301-303 alpha2B-adrenoceptor gene polymorphism with central hemodynamic parameters in the northern Russian population
title_sort associations of del 301-303 alpha2b-adrenoceptor gene polymorphism with central hemodynamic parameters in the northern russian population
topic PG SNPs
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867614/
https://www.ncbi.nlm.nih.gov/pubmed/29212846
http://dx.doi.org/10.1152/physiolgenomics.00071.2017
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