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Briaviolides K–N, New Briarane-Type Diterpenoids from Cultured Octocoral Briareum violaceum
Four new briarane diterpenoids, briaviolides K–N (1–4), have been obtained from the cultured-type octocoral Briareum violaceum. Using a spectroscopic approach, the structures of briaranes 1–4 were identified. This study employed an in vitro model of lipopolysaccharide (LPS)-induced inflammation in t...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867619/ https://www.ncbi.nlm.nih.gov/pubmed/29495481 http://dx.doi.org/10.3390/md16030075 |
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author | Xu, Jing-Hao Lai, Kuei-Hung Su, Yin-Di Chang, Yu-Chia Peng, Bo-Rong Backlund, Anders Wen, Zhi-Hong Sung, Ping-Jyun |
author_facet | Xu, Jing-Hao Lai, Kuei-Hung Su, Yin-Di Chang, Yu-Chia Peng, Bo-Rong Backlund, Anders Wen, Zhi-Hong Sung, Ping-Jyun |
author_sort | Xu, Jing-Hao |
collection | PubMed |
description | Four new briarane diterpenoids, briaviolides K–N (1–4), have been obtained from the cultured-type octocoral Briareum violaceum. Using a spectroscopic approach, the structures of briaranes 1–4 were identified. This study employed an in vitro model of lipopolysaccharide (LPS)-induced inflammation in the murine macrophage RAW 264.7 cell line, and found that among the four briaranes, briarane 2 possessed anti-inflammatory activity against inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expressions in cells. In addition, principal component analysis using the chemical global positioning system (ChemGPS) for natural products (ChemGPS-NP) was employed in order to analyze the structure-activity relationship (SAR), and the results indicated that the ring conformation of the compound has a leading role in suppressing the expressions of pro-inflammatory iNOS and COX-2 proteins in macrophages. |
format | Online Article Text |
id | pubmed-5867619 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-58676192018-03-27 Briaviolides K–N, New Briarane-Type Diterpenoids from Cultured Octocoral Briareum violaceum Xu, Jing-Hao Lai, Kuei-Hung Su, Yin-Di Chang, Yu-Chia Peng, Bo-Rong Backlund, Anders Wen, Zhi-Hong Sung, Ping-Jyun Mar Drugs Article Four new briarane diterpenoids, briaviolides K–N (1–4), have been obtained from the cultured-type octocoral Briareum violaceum. Using a spectroscopic approach, the structures of briaranes 1–4 were identified. This study employed an in vitro model of lipopolysaccharide (LPS)-induced inflammation in the murine macrophage RAW 264.7 cell line, and found that among the four briaranes, briarane 2 possessed anti-inflammatory activity against inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein expressions in cells. In addition, principal component analysis using the chemical global positioning system (ChemGPS) for natural products (ChemGPS-NP) was employed in order to analyze the structure-activity relationship (SAR), and the results indicated that the ring conformation of the compound has a leading role in suppressing the expressions of pro-inflammatory iNOS and COX-2 proteins in macrophages. MDPI 2018-02-27 /pmc/articles/PMC5867619/ /pubmed/29495481 http://dx.doi.org/10.3390/md16030075 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Xu, Jing-Hao Lai, Kuei-Hung Su, Yin-Di Chang, Yu-Chia Peng, Bo-Rong Backlund, Anders Wen, Zhi-Hong Sung, Ping-Jyun Briaviolides K–N, New Briarane-Type Diterpenoids from Cultured Octocoral Briareum violaceum |
title | Briaviolides K–N, New Briarane-Type Diterpenoids from Cultured Octocoral Briareum violaceum |
title_full | Briaviolides K–N, New Briarane-Type Diterpenoids from Cultured Octocoral Briareum violaceum |
title_fullStr | Briaviolides K–N, New Briarane-Type Diterpenoids from Cultured Octocoral Briareum violaceum |
title_full_unstemmed | Briaviolides K–N, New Briarane-Type Diterpenoids from Cultured Octocoral Briareum violaceum |
title_short | Briaviolides K–N, New Briarane-Type Diterpenoids from Cultured Octocoral Briareum violaceum |
title_sort | briaviolides k–n, new briarane-type diterpenoids from cultured octocoral briareum violaceum |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867619/ https://www.ncbi.nlm.nih.gov/pubmed/29495481 http://dx.doi.org/10.3390/md16030075 |
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