Cargando…

Synthesis and Biological Evaluation of a New Structural Simplified Analogue of cADPR, a Calcium-Mobilizing Secondary Messenger Firstly Isolated from Sea Urchin Eggs

Herein, we reported on the synthesis of cpIPP, which is a new structurally-reduced analogue of cyclic ADP-ribose (cADPR), a potent Ca(2+)-releasing secondary messenger that was firstly isolated from sea urchin eggs extracts. To obtain cpIPP the “northern” ribose of cADPR was replaced by a pentyl cha...

Descripción completa

Detalles Bibliográficos
Autores principales:	D’Errico, Stefano, Borbone, Nicola, Catalanotti, Bruno, Secondo, Agnese, Petrozziello, Tiziana, Piccialli, Ilaria, Pannaccione, Anna, Costantino, Valeria, Mayol, Luciano, Piccialli, Gennaro, Oliviero, Giorgia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867633/ https://www.ncbi.nlm.nih.gov/pubmed/29534435 http://dx.doi.org/10.3390/md16030089

Ejemplares similares

Synthesis of cyclic N(1)-pentylinosine phosphate, a new structurally reduced cADPR analogue with calcium-mobilizing activity on PC12 cells
por: Mahal, Ahmed, et al.
Publicado: (2015)

New Linear Precursors of cIDPR Derivatives as Stable Analogs of cADPR: A Potent Second Messenger with Ca(2+)-Modulating Activity Isolated from Sea Urchin Eggs
por: D’Errico, Stefano, et al.
Publicado: (2019)

Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-ribityl or 4-Hydroxybutyl Chains in Place of the Ribose
por: D’Errico, Stefano, et al.
Publicado: (2013)

A Facile Synthesis of 5′-Fluoro-5′-deoxyacadesine (5′-F-AICAR): A Novel Non-phosphorylable AICAR Analogue
por: D’Errico, Stefano, et al.
Publicado: (2012)

Solid-Phase Synthesis of a New Diphosphate 5-Aminoimidazole-4-carboxamide Riboside (AICAR) Derivative and Studies toward Cyclic AICAR Diphosphate Ribose
por: D’Errico, Stefano, et al.
Publicado: (2011)

5-Amino-1-(2′,3′-O-isopropylidene-d-ribityl)-1H-imidazole-4-carboxamide: a crystal structure with Z′ = 4
por: Piccialli, Vincenzo, et al.
Publicado: (2017)

cADPR Does Not Activate TRPM2
por: Riekehr, Winnie Maria, et al.
Publicado: (2022)

Concise Syntheses of Trifluoromethylated Cyclic and Acyclic Analogues of cADPR
por: Huang, Xiangchen, et al.
Publicado: (2010)

Synthesis and Pharmacological Evaluation of Modified Adenosines Joined to Mono-Functional Platinum Moieties
por: D’Errico, Stefano, et al.
Publicado: (2014)

Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes
por: Piccialli, Ilaria, et al.
Publicado: (2022)

Exploitation of a Very Small Peptide Nucleic Acid as a New Inhibitor of miR-509-3p Involved in the Regulation of Cystic Fibrosis Disease-Gene Expression
por: Amato, Felice, et al.
Publicado: (2014)

Synthetic cADPR analogues may form only one of two possible conformational diastereoisomers
por: Watt, Joanna M., et al.
Publicado: (2018)

CD38/cADPR Signaling Pathway in Airway Disease: Regulatory Mechanisms
por: Deshpande, Deepak A., et al.
Publicado: (2018)

cADPR induced calcium influx mediates axonal degeneration caused by paclitaxel
por: Höke, Ahmet
Publicado: (2022)

Self‐Assembly of G‐Rich Oligonucleotides Incorporating a 3′–3′ Inversion of Polarity Site: A New Route Towards G‐Wire DNA Nanostructures
por: Oliviero, Giorgia, et al.
Publicado: (2017)

Evaluation of an Analogue of the Marine ε-PLL Peptide as a Ligand of G-quadruplex DNA Structures
por: Marzano, Maria, et al.
Publicado: (2020)

Peptide Nucleic Acids as miRNA Target Protectors for the Treatment of Cystic Fibrosis
por: Zarrilli, Federica, et al.
Publicado: (2017)

Arginine Thiazolidine Carboxylate Stimulates Insulin Secretion through Production of Ca(2+)-Mobilizing Second Messengers NAADP and cADPR in Pancreatic Islets
por: Park, Dae-Ryoung, et al.
Publicado: (2015)

Synthesis of the Ca(2+)-mobilizing messengers NAADP and cADPR by intracellular CD38 enzyme in the mouse heart: Role in β-adrenoceptor signaling
por: Lin, Wee K., et al.
Publicado: (2017)

Synthesis and Calcium Mobilization Activity of cADPR Analogues Which Integrate Nucleobase, Northern and Southern Ribose Modifications
por: Zhou, Yue, et al.
Publicado: (2012)

Synthesis of cyclic adenosine 5′-diphosphate ribose analogues: a C2′ endo/syn “southern” ribose conformation underlies activity at the sea urchin cADPR receptor
por: Moreau, Christelle, et al.
Publicado: (2011)

New G-Quadruplex-Forming Oligodeoxynucleotides Incorporating a Bifunctional Double-Ended Linker (DEL): Effects of DEL Size and ODNs Orientation on the Topology, Stability, and Molecularity of DEL-G-Quadruplexes
por: Marzano, Maria, et al.
Publicado: (2019)

Nucleoside Analogs and Nucleoside Precursors as Drugs in the Fight against SARS-CoV-2 and Other Coronaviruses
por: Borbone, Nicola, et al.
Publicado: (2021)

Does Cyclic ADP-Ribose (cADPR) Activate the Non-selective Cation Channel TRPM2?
por: Fliegert, Ralf, et al.
Publicado: (2020)

A novel mechanism of imeglimin‐mediated insulin secretion via the cADPR‐TRP channel pathway
por: Funazaki, Shunsuke, et al.
Publicado: (2021)

Synthesis of mixed-sequence oligonucleotides on mesoporous silicon: chemical strategies and material stability
por: Terracciano, Monica, et al.
Publicado: (2014)

d(CGGTGGT) forms an octameric parallel G-quadruplex via stacking of unusual G(:C):G(:C):G(:C):G(:C) octads
por: Borbone, Nicola, et al.
Publicado: (2011)

Sarm1 activation produces cADPR to increase intra-axonal Ca(++) and promote axon degeneration in PIPN
por: Li, Yihang, et al.
Publicado: (2021)

Inhibition of Cardiomyocytes Differentiation of Mouse Embryonic Stem Cells by CD38/cADPR/Ca(2+) Signaling Pathway
por: Wei, Wen-Jie, et al.
Publicado: (2012)

Increased K(V)2.1 Channel Clustering Underlies the Reduction of Delayed Rectifier K(+) Currents in Hippocampal Neurons of the Tg2576 Alzheimer’s Disease Mouse
por: Piccialli, Ilaria, et al.
Publicado: (2022)

Nucleic Acids as Biotools at the Interface between Chemistry and Nanomedicine in the COVID-19 Era
por: Borbone, Nicola, et al.
Publicado: (2022)

Probing the DNA Reactivity and the Anticancer Properties of a Novel Tubercidin-Pt(II) Complex
por: D’Errico, Stefano, et al.
Publicado: (2020)

Synthesis of phosphonoacetate analogues of the second messenger adenosine 5′-diphosphate ribose (ADPR)
por: Baszczyňski, Ondřej, et al.
Publicado: (2020)

Design, Synthesis and Characterization of Novel Co-Polymers Decorated with Peptides for the Selective Nanoparticle Transport across the Cerebral Endothelium
por: Falanga, Andrea P., et al.
Publicado: (2018)

The Antioxidant Activity of Limonene Counteracts Neurotoxicity Triggered byAβ(1-42) Oligomers in Primary Cortical Neurons
por: Piccialli, Ilaria, et al.
Publicado: (2021)

Size-Based Effects of Anthropogenic Ultrafine Particles on Lysosomal TRPML1 Channel and Autophagy in Motoneuron-like Cells
por: Sapienza, Silvia, et al.
Publicado: (2022)

Exploring the Parallel G-Quadruplex Nucleic Acid World: A Spectroscopic and Computational Investigation on the Binding of the c-myc Oncogene NHE III1 Region by the Phytochemical Polydatin
por: Greco, Francesca, et al.
Publicado: (2022)

3β,6α-Diacetoxy-5,9α-dihydroxy-5α-cholest-7-en-11-one
por: Piccialli, Vincenzo, et al.
Publicado: (2013)

3β,6β-Diacetoxy-5,9α-dihydroxy-5α-cholest-7-en-11-one acetic acid 0.04-solvate
por: Piccialli, Vincenzo, et al.
Publicado: (2013)

The Anemonia sulcata Toxin BDS-I Protects Astrocytes Exposed to Aβ(1–42) Oligomers by Restoring [Ca(2+)](i) Transients and ER Ca(2+) Signaling
por: Piccialli, Ilaria, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_0us5dcgknfola0g0erv1tvaunq