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Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Culcita novaeguineae

Four new polyhydroxysteroidal glycosides—culcinosides A–D (1, 2, 4, and 7)—along with three known compounds—echinasteroside C (3), linckoside F (5), and linckoside L3 (6)—were isolated from the ethanol extract of starfish Culcita novaeguineae collected from the Xisha Islands of the South China Sea....

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Autores principales: Lu, Yunyang, Li, Hu, Wang, Minchang, Liu, Yang, Feng, Yingda, Liu, Ke, Tang, Haifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867636/
https://www.ncbi.nlm.nih.gov/pubmed/29534028
http://dx.doi.org/10.3390/md16030092
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author Lu, Yunyang
Li, Hu
Wang, Minchang
Liu, Yang
Feng, Yingda
Liu, Ke
Tang, Haifeng
author_facet Lu, Yunyang
Li, Hu
Wang, Minchang
Liu, Yang
Feng, Yingda
Liu, Ke
Tang, Haifeng
author_sort Lu, Yunyang
collection PubMed
description Four new polyhydroxysteroidal glycosides—culcinosides A–D (1, 2, 4, and 7)—along with three known compounds—echinasteroside C (3), linckoside F (5), and linckoside L3 (6)—were isolated from the ethanol extract of starfish Culcita novaeguineae collected from the Xisha Islands of the South China Sea. The structures of new compounds were elucidated through extensive spectroscopic studies and chemical evidence, especially two-dimensional (2D) NMR techniques. The cytotoxicity of the new compounds against human glioblastoma cell lines U87, U251, and SHG44 were evaluated.
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spelling pubmed-58676362018-03-27 Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Culcita novaeguineae Lu, Yunyang Li, Hu Wang, Minchang Liu, Yang Feng, Yingda Liu, Ke Tang, Haifeng Mar Drugs Article Four new polyhydroxysteroidal glycosides—culcinosides A–D (1, 2, 4, and 7)—along with three known compounds—echinasteroside C (3), linckoside F (5), and linckoside L3 (6)—were isolated from the ethanol extract of starfish Culcita novaeguineae collected from the Xisha Islands of the South China Sea. The structures of new compounds were elucidated through extensive spectroscopic studies and chemical evidence, especially two-dimensional (2D) NMR techniques. The cytotoxicity of the new compounds against human glioblastoma cell lines U87, U251, and SHG44 were evaluated. MDPI 2018-03-13 /pmc/articles/PMC5867636/ /pubmed/29534028 http://dx.doi.org/10.3390/md16030092 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lu, Yunyang
Li, Hu
Wang, Minchang
Liu, Yang
Feng, Yingda
Liu, Ke
Tang, Haifeng
Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Culcita novaeguineae
title Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Culcita novaeguineae
title_full Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Culcita novaeguineae
title_fullStr Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Culcita novaeguineae
title_full_unstemmed Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Culcita novaeguineae
title_short Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Culcita novaeguineae
title_sort cytotoxic polyhydroxysteroidal glycosides from starfish culcita novaeguineae
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867636/
https://www.ncbi.nlm.nih.gov/pubmed/29534028
http://dx.doi.org/10.3390/md16030092
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