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Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Culcita novaeguineae
Four new polyhydroxysteroidal glycosides—culcinosides A–D (1, 2, 4, and 7)—along with three known compounds—echinasteroside C (3), linckoside F (5), and linckoside L3 (6)—were isolated from the ethanol extract of starfish Culcita novaeguineae collected from the Xisha Islands of the South China Sea....
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867636/ https://www.ncbi.nlm.nih.gov/pubmed/29534028 http://dx.doi.org/10.3390/md16030092 |
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author | Lu, Yunyang Li, Hu Wang, Minchang Liu, Yang Feng, Yingda Liu, Ke Tang, Haifeng |
author_facet | Lu, Yunyang Li, Hu Wang, Minchang Liu, Yang Feng, Yingda Liu, Ke Tang, Haifeng |
author_sort | Lu, Yunyang |
collection | PubMed |
description | Four new polyhydroxysteroidal glycosides—culcinosides A–D (1, 2, 4, and 7)—along with three known compounds—echinasteroside C (3), linckoside F (5), and linckoside L3 (6)—were isolated from the ethanol extract of starfish Culcita novaeguineae collected from the Xisha Islands of the South China Sea. The structures of new compounds were elucidated through extensive spectroscopic studies and chemical evidence, especially two-dimensional (2D) NMR techniques. The cytotoxicity of the new compounds against human glioblastoma cell lines U87, U251, and SHG44 were evaluated. |
format | Online Article Text |
id | pubmed-5867636 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-58676362018-03-27 Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Culcita novaeguineae Lu, Yunyang Li, Hu Wang, Minchang Liu, Yang Feng, Yingda Liu, Ke Tang, Haifeng Mar Drugs Article Four new polyhydroxysteroidal glycosides—culcinosides A–D (1, 2, 4, and 7)—along with three known compounds—echinasteroside C (3), linckoside F (5), and linckoside L3 (6)—were isolated from the ethanol extract of starfish Culcita novaeguineae collected from the Xisha Islands of the South China Sea. The structures of new compounds were elucidated through extensive spectroscopic studies and chemical evidence, especially two-dimensional (2D) NMR techniques. The cytotoxicity of the new compounds against human glioblastoma cell lines U87, U251, and SHG44 were evaluated. MDPI 2018-03-13 /pmc/articles/PMC5867636/ /pubmed/29534028 http://dx.doi.org/10.3390/md16030092 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lu, Yunyang Li, Hu Wang, Minchang Liu, Yang Feng, Yingda Liu, Ke Tang, Haifeng Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Culcita novaeguineae |
title | Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Culcita novaeguineae |
title_full | Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Culcita novaeguineae |
title_fullStr | Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Culcita novaeguineae |
title_full_unstemmed | Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Culcita novaeguineae |
title_short | Cytotoxic Polyhydroxysteroidal Glycosides from Starfish Culcita novaeguineae |
title_sort | cytotoxic polyhydroxysteroidal glycosides from starfish culcita novaeguineae |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867636/ https://www.ncbi.nlm.nih.gov/pubmed/29534028 http://dx.doi.org/10.3390/md16030092 |
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