Targeting Multiple Effector Pathways in Pancreatic Ductal Adenocarcinoma with a G-Quadruplex-Binding Small Molecule

[Image: see text] Human pancreatic ductal adenocarcinoma (PDAC) involves the dysregulation of multiple signaling pathways. A novel approach to the treatment of PDAC is described, involving the targeting of cancer genes in PDAC pathways having over-representation of G-quadruplexes, using the trisubst...

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Detalles Bibliográficos
Autores principales: Marchetti, Chiara, Zyner, Katherine G., Ohnmacht, Stephan A., Robson, Mathew, Haider, Shozeb M., Morton, Jennifer P., Marsico, Giovanni, Vo, Tam, Laughlin-Toth, Sarah, Ahmed, Ahmed A., Di Vita, Gloria, Pazitna, Ingrida, Gunaratnam, Mekala, Besser, Rachael J., Andrade, Ana C. G., Diocou, Seckou, Pike, Jeremy A., Tannahill, David, Pedley, R. Barbara, Evans, T. R. Jeffry, Wilson, W. David, Balasubramanian, Shankar, Neidle, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867665/
https://www.ncbi.nlm.nih.gov/pubmed/29356532
http://dx.doi.org/10.1021/acs.jmedchem.7b01781

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