Alternative Splicing in the Hippo Pathway—Implications for Disease and Potential Therapeutic Targets

Alternative splicing is a well-studied gene regulatory mechanism that produces biological diversity by allowing the production of multiple protein isoforms from a single gene. An involvement of alternative splicing in the key biological signalling Hippo pathway is emerging and offers new therapeutic...

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Detalles Bibliográficos
Autores principales: Porazinski, Sean, Ladomery, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867882/
https://www.ncbi.nlm.nih.gov/pubmed/29534050
http://dx.doi.org/10.3390/genes9030161
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author Porazinski, Sean
Ladomery, Michael
author_facet Porazinski, Sean
Ladomery, Michael
author_sort Porazinski, Sean
collection PubMed
description Alternative splicing is a well-studied gene regulatory mechanism that produces biological diversity by allowing the production of multiple protein isoforms from a single gene. An involvement of alternative splicing in the key biological signalling Hippo pathway is emerging and offers new therapeutic avenues. This review discusses examples of alternative splicing in the Hippo pathway, how deregulation of these processes may contribute to disease and whether these processes offer new potential therapeutic targets.
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spelling pubmed-58678822018-03-27 Alternative Splicing in the Hippo Pathway—Implications for Disease and Potential Therapeutic Targets Porazinski, Sean Ladomery, Michael Genes (Basel) Review Alternative splicing is a well-studied gene regulatory mechanism that produces biological diversity by allowing the production of multiple protein isoforms from a single gene. An involvement of alternative splicing in the key biological signalling Hippo pathway is emerging and offers new therapeutic avenues. This review discusses examples of alternative splicing in the Hippo pathway, how deregulation of these processes may contribute to disease and whether these processes offer new potential therapeutic targets. MDPI 2018-03-13 /pmc/articles/PMC5867882/ /pubmed/29534050 http://dx.doi.org/10.3390/genes9030161 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Porazinski, Sean
Ladomery, Michael
Alternative Splicing in the Hippo Pathway—Implications for Disease and Potential Therapeutic Targets
title Alternative Splicing in the Hippo Pathway—Implications for Disease and Potential Therapeutic Targets
title_full Alternative Splicing in the Hippo Pathway—Implications for Disease and Potential Therapeutic Targets
title_fullStr Alternative Splicing in the Hippo Pathway—Implications for Disease and Potential Therapeutic Targets
title_full_unstemmed Alternative Splicing in the Hippo Pathway—Implications for Disease and Potential Therapeutic Targets
title_short Alternative Splicing in the Hippo Pathway—Implications for Disease and Potential Therapeutic Targets
title_sort alternative splicing in the hippo pathway—implications for disease and potential therapeutic targets
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5867882/
https://www.ncbi.nlm.nih.gov/pubmed/29534050
http://dx.doi.org/10.3390/genes9030161
work_keys_str_mv AT porazinskisean alternativesplicinginthehippopathwayimplicationsfordiseaseandpotentialtherapeutictargets
AT ladomerymichael alternativesplicinginthehippopathwayimplicationsfordiseaseandpotentialtherapeutictargets

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