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Site-specific detection of protein secondary structure using 2D IR dihedral indexing: a proposed assembly mechanism of oligomeric hIAPP

Human islet amyloid polypeptide (hIAPP) aggregates into fibrils through oligomers that have been postulated to contain α-helices as well as β-sheets. We employ a site-specific isotope labeling strategy that is capable of detecting changes in dihedral angles when used in conjunction with 2D IR spectr...

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Detalles Bibliográficos
Autores principales:	Maj, Michał, Lomont, Justin P., Rich, Kacie L., Alperstein, Ariel M., Zanni, Martin T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2017
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868010/ https://www.ncbi.nlm.nih.gov/pubmed/29619202 http://dx.doi.org/10.1039/c7sc03789a

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