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Achieving efficient photodynamic therapy under both normoxia and hypoxia using cyclometalated Ru(ii) photosensitizer through type I photochemical process
Photodynamic therapy (PDT) through the generation of singlet oxygen utilizing photosensitizers (PSs) is significantly limited under hypoxic conditions in solid tumors. So it is meaningful to develop effective PSs which can maintain excellent therapeutic effects under hypoxia. Here we reported a coum...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal Society of Chemistry
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868078/ https://www.ncbi.nlm.nih.gov/pubmed/29619206 http://dx.doi.org/10.1039/c7sc03765a |
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author | Lv, Zhuang Wei, Huanjie Li, Qing Su, Xianlong Liu, Shujuan Zhang, Kenneth Yin Lv, Wen Zhao, Qiang Li, Xianghong Huang, Wei |
author_facet | Lv, Zhuang Wei, Huanjie Li, Qing Su, Xianlong Liu, Shujuan Zhang, Kenneth Yin Lv, Wen Zhao, Qiang Li, Xianghong Huang, Wei |
author_sort | Lv, Zhuang |
collection | PubMed |
description | Photodynamic therapy (PDT) through the generation of singlet oxygen utilizing photosensitizers (PSs) is significantly limited under hypoxic conditions in solid tumors. So it is meaningful to develop effective PSs which can maintain excellent therapeutic effects under hypoxia. Here we reported a coumarin-modified cyclometalated Ru(ii) photosensitizer (Ru2), which exhibits lower oxidation potential and stronger absorption in the visible region than the coumarin-free counterpart. The evaluation of the PDT effect was performed under both normoxia and hypoxia. The results showed that Ru2 has a better therapeutic effect than the coumarin-free counterpart in in vitro experiments. Especially under hypoxia, Ru2 still retained an excellent PDT effect, which can be attributed to the direct charge transfer between the excited PS and an adjacent substrate through a type I photochemical process, forming highly-oxidative hydroxyl radicals to damage tumor cells. The anti-tumor activity of Ru2 was further proven to be effective in tumor-bearing mice, and tumor growth was inhibited remarkably under PDT treatment. |
format | Online Article Text |
id | pubmed-5868078 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-58680782018-04-04 Achieving efficient photodynamic therapy under both normoxia and hypoxia using cyclometalated Ru(ii) photosensitizer through type I photochemical process Lv, Zhuang Wei, Huanjie Li, Qing Su, Xianlong Liu, Shujuan Zhang, Kenneth Yin Lv, Wen Zhao, Qiang Li, Xianghong Huang, Wei Chem Sci Chemistry Photodynamic therapy (PDT) through the generation of singlet oxygen utilizing photosensitizers (PSs) is significantly limited under hypoxic conditions in solid tumors. So it is meaningful to develop effective PSs which can maintain excellent therapeutic effects under hypoxia. Here we reported a coumarin-modified cyclometalated Ru(ii) photosensitizer (Ru2), which exhibits lower oxidation potential and stronger absorption in the visible region than the coumarin-free counterpart. The evaluation of the PDT effect was performed under both normoxia and hypoxia. The results showed that Ru2 has a better therapeutic effect than the coumarin-free counterpart in in vitro experiments. Especially under hypoxia, Ru2 still retained an excellent PDT effect, which can be attributed to the direct charge transfer between the excited PS and an adjacent substrate through a type I photochemical process, forming highly-oxidative hydroxyl radicals to damage tumor cells. The anti-tumor activity of Ru2 was further proven to be effective in tumor-bearing mice, and tumor growth was inhibited remarkably under PDT treatment. Royal Society of Chemistry 2017-10-31 /pmc/articles/PMC5868078/ /pubmed/29619206 http://dx.doi.org/10.1039/c7sc03765a Text en This journal is © The Royal Society of Chemistry 2018 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0) |
spellingShingle | Chemistry Lv, Zhuang Wei, Huanjie Li, Qing Su, Xianlong Liu, Shujuan Zhang, Kenneth Yin Lv, Wen Zhao, Qiang Li, Xianghong Huang, Wei Achieving efficient photodynamic therapy under both normoxia and hypoxia using cyclometalated Ru(ii) photosensitizer through type I photochemical process |
title | Achieving efficient photodynamic therapy under both normoxia and hypoxia using cyclometalated Ru(ii) photosensitizer through type I photochemical process
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title_full | Achieving efficient photodynamic therapy under both normoxia and hypoxia using cyclometalated Ru(ii) photosensitizer through type I photochemical process
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title_fullStr | Achieving efficient photodynamic therapy under both normoxia and hypoxia using cyclometalated Ru(ii) photosensitizer through type I photochemical process
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title_full_unstemmed | Achieving efficient photodynamic therapy under both normoxia and hypoxia using cyclometalated Ru(ii) photosensitizer through type I photochemical process
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title_short | Achieving efficient photodynamic therapy under both normoxia and hypoxia using cyclometalated Ru(ii) photosensitizer through type I photochemical process
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title_sort | achieving efficient photodynamic therapy under both normoxia and hypoxia using cyclometalated ru(ii) photosensitizer through type i photochemical process |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868078/ https://www.ncbi.nlm.nih.gov/pubmed/29619206 http://dx.doi.org/10.1039/c7sc03765a |
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