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Cancer survival in patients from a hospital-based cancer registry, China

Purpose: There are few reports on survival rate analysis from hospital-based cancer registries (HBCR) in China, although the National Center of Cancer Registry of China has launched such an effort with the mission to expand the scope of registration and follow-up. Our study aimed to evaluate surviva...

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Autores principales: Chen, Jian-Guo, Chen, Hai-Zhen, Zhu, Jian, Yang, Yan-Lei, Zhang, Yong-Hui, Huang, Pei-Xin, Chen, Yong-Sheng, Zhu, Chao-Yong, Yang, Li-Ping, Shen, Kang, Qiang, Fu-Lin, Wang, Gao-Ren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868149/
https://www.ncbi.nlm.nih.gov/pubmed/29581763
http://dx.doi.org/10.7150/jca.23039
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author Chen, Jian-Guo
Chen, Hai-Zhen
Zhu, Jian
Yang, Yan-Lei
Zhang, Yong-Hui
Huang, Pei-Xin
Chen, Yong-Sheng
Zhu, Chao-Yong
Yang, Li-Ping
Shen, Kang
Qiang, Fu-Lin
Wang, Gao-Ren
author_facet Chen, Jian-Guo
Chen, Hai-Zhen
Zhu, Jian
Yang, Yan-Lei
Zhang, Yong-Hui
Huang, Pei-Xin
Chen, Yong-Sheng
Zhu, Chao-Yong
Yang, Li-Ping
Shen, Kang
Qiang, Fu-Lin
Wang, Gao-Ren
author_sort Chen, Jian-Guo
collection PubMed
description Purpose: There are few reports on survival rate analysis from hospital-based cancer registries (HBCR) in China, although the National Center of Cancer Registry of China has launched such an effort with the mission to expand the scope of registration and follow-up. Our study aimed to evaluate survival and outcomes of cancer patients from a HBCR in eastern China. Methods: Active and passive follow-up methods were used to obtain information on survival status for all patients from Qidong City and Haimen City in the databases of our hospital-based registrations from 2002 to 2014. Censor time for survival was 31(st) March, 2016. Survival probability was estimated using the life-table method with SPSS Statistics software, and comparison of significant differences in survival rates was tested by Wilcoxon (Gehan) statistic. Results: The outcomes of 5010 patients were identified in the follow-up for 5244 cases from Qidong and Haimen, with a follow-up rate of 95.65%, and a rate of lost to follow-up of 4.35%. The 1-, 3-, 5-, and 10-year observed survival (OS) rate in all-combined cancer sites were 59.80%, 37.70%, 30.82%, and 22.60%, respectively. The top 10 cancer sites in rank were cancers of lung, esophagus, liver, cervix, stomach, breast, colon-rectum, non-Hodgkin's lymphoma, nasopharynx, and ovary, with 5-year OS rates of 12.63%, 19.62%, 11.69%, 66.61%, 21.35%, 59.43%, 36.36%, 37.03%, 48.95% and 36.17%, respectively. Females experienced better survival than males for lung, esophageal, liver, nasopharyngeal and pancreatic cancers (P<0.05), but not for other sites (P>0.05). A significant difference was also found between males and females when all-sites were combined (P<0.01). There are significant differences (P<0.05) between the 2015 patients (from Qidong) and the 3001 patients (from Haimen) with 5-year OS rates of 32.72% vs 29.57%; no significant differences were found for 5-year OS rates for individual cancer sites (P>0.05) except for liver (P=0.0005) and ovary (P=0.0460) between the two cities. Younger patients had better prognosis, but significance was only seen in cervical (P=0.0102) and nasopharyngeal (P=0.0305) cancers. Conclusion: The survival rates of each site or of all sites-combined in this setting are consistent with those elsewhere in China and abroad. Discrepancies in overall survival could be affected by the proportion of sites with or without better prognosis. Hospital-based cancer survival is a better index to evaluate outcomes that reflect the levels of comprehensive treatment and improvement of medical and health services.
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spelling pubmed-58681492018-03-26 Cancer survival in patients from a hospital-based cancer registry, China Chen, Jian-Guo Chen, Hai-Zhen Zhu, Jian Yang, Yan-Lei Zhang, Yong-Hui Huang, Pei-Xin Chen, Yong-Sheng Zhu, Chao-Yong Yang, Li-Ping Shen, Kang Qiang, Fu-Lin Wang, Gao-Ren J Cancer Research Paper Purpose: There are few reports on survival rate analysis from hospital-based cancer registries (HBCR) in China, although the National Center of Cancer Registry of China has launched such an effort with the mission to expand the scope of registration and follow-up. Our study aimed to evaluate survival and outcomes of cancer patients from a HBCR in eastern China. Methods: Active and passive follow-up methods were used to obtain information on survival status for all patients from Qidong City and Haimen City in the databases of our hospital-based registrations from 2002 to 2014. Censor time for survival was 31(st) March, 2016. Survival probability was estimated using the life-table method with SPSS Statistics software, and comparison of significant differences in survival rates was tested by Wilcoxon (Gehan) statistic. Results: The outcomes of 5010 patients were identified in the follow-up for 5244 cases from Qidong and Haimen, with a follow-up rate of 95.65%, and a rate of lost to follow-up of 4.35%. The 1-, 3-, 5-, and 10-year observed survival (OS) rate in all-combined cancer sites were 59.80%, 37.70%, 30.82%, and 22.60%, respectively. The top 10 cancer sites in rank were cancers of lung, esophagus, liver, cervix, stomach, breast, colon-rectum, non-Hodgkin's lymphoma, nasopharynx, and ovary, with 5-year OS rates of 12.63%, 19.62%, 11.69%, 66.61%, 21.35%, 59.43%, 36.36%, 37.03%, 48.95% and 36.17%, respectively. Females experienced better survival than males for lung, esophageal, liver, nasopharyngeal and pancreatic cancers (P<0.05), but not for other sites (P>0.05). A significant difference was also found between males and females when all-sites were combined (P<0.01). There are significant differences (P<0.05) between the 2015 patients (from Qidong) and the 3001 patients (from Haimen) with 5-year OS rates of 32.72% vs 29.57%; no significant differences were found for 5-year OS rates for individual cancer sites (P>0.05) except for liver (P=0.0005) and ovary (P=0.0460) between the two cities. Younger patients had better prognosis, but significance was only seen in cervical (P=0.0102) and nasopharyngeal (P=0.0305) cancers. Conclusion: The survival rates of each site or of all sites-combined in this setting are consistent with those elsewhere in China and abroad. Discrepancies in overall survival could be affected by the proportion of sites with or without better prognosis. Hospital-based cancer survival is a better index to evaluate outcomes that reflect the levels of comprehensive treatment and improvement of medical and health services. Ivyspring International Publisher 2018-02-12 /pmc/articles/PMC5868149/ /pubmed/29581763 http://dx.doi.org/10.7150/jca.23039 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Chen, Jian-Guo
Chen, Hai-Zhen
Zhu, Jian
Yang, Yan-Lei
Zhang, Yong-Hui
Huang, Pei-Xin
Chen, Yong-Sheng
Zhu, Chao-Yong
Yang, Li-Ping
Shen, Kang
Qiang, Fu-Lin
Wang, Gao-Ren
Cancer survival in patients from a hospital-based cancer registry, China
title Cancer survival in patients from a hospital-based cancer registry, China
title_full Cancer survival in patients from a hospital-based cancer registry, China
title_fullStr Cancer survival in patients from a hospital-based cancer registry, China
title_full_unstemmed Cancer survival in patients from a hospital-based cancer registry, China
title_short Cancer survival in patients from a hospital-based cancer registry, China
title_sort cancer survival in patients from a hospital-based cancer registry, china
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868149/
https://www.ncbi.nlm.nih.gov/pubmed/29581763
http://dx.doi.org/10.7150/jca.23039
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