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SULT1E1 inhibits cell proliferation and invasion by activating PPARγ in breast cancer
Sulfotransferase family 1E member 1 (SULT1E1) is known to catalyze sulfoconjugation and play a crucial role in the deactivation of estrogen homeostasis, which is involved in tumorigenesis and the progression of breast and endometrial cancers. Our previous study has shown that the protein levels of S...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868175/ https://www.ncbi.nlm.nih.gov/pubmed/29581787 http://dx.doi.org/10.7150/jca.23596 |
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author | Xu, Yali Lin, Xiaoyan Xu, Jiawen Jing, Haiyan Qin, Yejun Li, Yintao |
author_facet | Xu, Yali Lin, Xiaoyan Xu, Jiawen Jing, Haiyan Qin, Yejun Li, Yintao |
author_sort | Xu, Yali |
collection | PubMed |
description | Sulfotransferase family 1E member 1 (SULT1E1) is known to catalyze sulfoconjugation and play a crucial role in the deactivation of estrogen homeostasis, which is involved in tumorigenesis and the progression of breast and endometrial cancers. Our previous study has shown that the protein levels of SULT1E1 were decreased in breast cancer; however, the underlying mechanism is still poorly understood. In this study, we explored the functional and molecular mechanisms by which SULT1E1 influenced breast cancer. Here, we identified that overexpression of SULT1E1 inhibited breast cancer cell growth through inducing apoptosis and arresting cell cycle progression. Furthermore, enforced expression of SULT1E1 suppressed tumor cell migration and invasion. Moreover, we found that the activation of PPARγ was required for SULT1E1-mediated downregulation of C-myc, Cyclin D1, MMP-2 and MMP-9 as well as for cell apoptosis, migration and invasion. In addition, the overexpression of SULT1E1 significantly inhibited tumor growth in vivo. Taken together, our findings indicated that SULT1E1 performed its tumor suppressor characteristics by activating PPARγ, which provided a novel target for patients with breast cancer. |
format | Online Article Text |
id | pubmed-5868175 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Ivyspring International Publisher |
record_format | MEDLINE/PubMed |
spelling | pubmed-58681752018-03-26 SULT1E1 inhibits cell proliferation and invasion by activating PPARγ in breast cancer Xu, Yali Lin, Xiaoyan Xu, Jiawen Jing, Haiyan Qin, Yejun Li, Yintao J Cancer Research Paper Sulfotransferase family 1E member 1 (SULT1E1) is known to catalyze sulfoconjugation and play a crucial role in the deactivation of estrogen homeostasis, which is involved in tumorigenesis and the progression of breast and endometrial cancers. Our previous study has shown that the protein levels of SULT1E1 were decreased in breast cancer; however, the underlying mechanism is still poorly understood. In this study, we explored the functional and molecular mechanisms by which SULT1E1 influenced breast cancer. Here, we identified that overexpression of SULT1E1 inhibited breast cancer cell growth through inducing apoptosis and arresting cell cycle progression. Furthermore, enforced expression of SULT1E1 suppressed tumor cell migration and invasion. Moreover, we found that the activation of PPARγ was required for SULT1E1-mediated downregulation of C-myc, Cyclin D1, MMP-2 and MMP-9 as well as for cell apoptosis, migration and invasion. In addition, the overexpression of SULT1E1 significantly inhibited tumor growth in vivo. Taken together, our findings indicated that SULT1E1 performed its tumor suppressor characteristics by activating PPARγ, which provided a novel target for patients with breast cancer. Ivyspring International Publisher 2018-02-28 /pmc/articles/PMC5868175/ /pubmed/29581787 http://dx.doi.org/10.7150/jca.23596 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
spellingShingle | Research Paper Xu, Yali Lin, Xiaoyan Xu, Jiawen Jing, Haiyan Qin, Yejun Li, Yintao SULT1E1 inhibits cell proliferation and invasion by activating PPARγ in breast cancer |
title | SULT1E1 inhibits cell proliferation and invasion by activating PPARγ in breast cancer |
title_full | SULT1E1 inhibits cell proliferation and invasion by activating PPARγ in breast cancer |
title_fullStr | SULT1E1 inhibits cell proliferation and invasion by activating PPARγ in breast cancer |
title_full_unstemmed | SULT1E1 inhibits cell proliferation and invasion by activating PPARγ in breast cancer |
title_short | SULT1E1 inhibits cell proliferation and invasion by activating PPARγ in breast cancer |
title_sort | sult1e1 inhibits cell proliferation and invasion by activating pparγ in breast cancer |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868175/ https://www.ncbi.nlm.nih.gov/pubmed/29581787 http://dx.doi.org/10.7150/jca.23596 |
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