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SULT1E1 inhibits cell proliferation and invasion by activating PPARγ in breast cancer

Sulfotransferase family 1E member 1 (SULT1E1) is known to catalyze sulfoconjugation and play a crucial role in the deactivation of estrogen homeostasis, which is involved in tumorigenesis and the progression of breast and endometrial cancers. Our previous study has shown that the protein levels of S...

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Autores principales: Xu, Yali, Lin, Xiaoyan, Xu, Jiawen, Jing, Haiyan, Qin, Yejun, Li, Yintao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868175/
https://www.ncbi.nlm.nih.gov/pubmed/29581787
http://dx.doi.org/10.7150/jca.23596
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author Xu, Yali
Lin, Xiaoyan
Xu, Jiawen
Jing, Haiyan
Qin, Yejun
Li, Yintao
author_facet Xu, Yali
Lin, Xiaoyan
Xu, Jiawen
Jing, Haiyan
Qin, Yejun
Li, Yintao
author_sort Xu, Yali
collection PubMed
description Sulfotransferase family 1E member 1 (SULT1E1) is known to catalyze sulfoconjugation and play a crucial role in the deactivation of estrogen homeostasis, which is involved in tumorigenesis and the progression of breast and endometrial cancers. Our previous study has shown that the protein levels of SULT1E1 were decreased in breast cancer; however, the underlying mechanism is still poorly understood. In this study, we explored the functional and molecular mechanisms by which SULT1E1 influenced breast cancer. Here, we identified that overexpression of SULT1E1 inhibited breast cancer cell growth through inducing apoptosis and arresting cell cycle progression. Furthermore, enforced expression of SULT1E1 suppressed tumor cell migration and invasion. Moreover, we found that the activation of PPARγ was required for SULT1E1-mediated downregulation of C-myc, Cyclin D1, MMP-2 and MMP-9 as well as for cell apoptosis, migration and invasion. In addition, the overexpression of SULT1E1 significantly inhibited tumor growth in vivo. Taken together, our findings indicated that SULT1E1 performed its tumor suppressor characteristics by activating PPARγ, which provided a novel target for patients with breast cancer.
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spelling pubmed-58681752018-03-26 SULT1E1 inhibits cell proliferation and invasion by activating PPARγ in breast cancer Xu, Yali Lin, Xiaoyan Xu, Jiawen Jing, Haiyan Qin, Yejun Li, Yintao J Cancer Research Paper Sulfotransferase family 1E member 1 (SULT1E1) is known to catalyze sulfoconjugation and play a crucial role in the deactivation of estrogen homeostasis, which is involved in tumorigenesis and the progression of breast and endometrial cancers. Our previous study has shown that the protein levels of SULT1E1 were decreased in breast cancer; however, the underlying mechanism is still poorly understood. In this study, we explored the functional and molecular mechanisms by which SULT1E1 influenced breast cancer. Here, we identified that overexpression of SULT1E1 inhibited breast cancer cell growth through inducing apoptosis and arresting cell cycle progression. Furthermore, enforced expression of SULT1E1 suppressed tumor cell migration and invasion. Moreover, we found that the activation of PPARγ was required for SULT1E1-mediated downregulation of C-myc, Cyclin D1, MMP-2 and MMP-9 as well as for cell apoptosis, migration and invasion. In addition, the overexpression of SULT1E1 significantly inhibited tumor growth in vivo. Taken together, our findings indicated that SULT1E1 performed its tumor suppressor characteristics by activating PPARγ, which provided a novel target for patients with breast cancer. Ivyspring International Publisher 2018-02-28 /pmc/articles/PMC5868175/ /pubmed/29581787 http://dx.doi.org/10.7150/jca.23596 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Xu, Yali
Lin, Xiaoyan
Xu, Jiawen
Jing, Haiyan
Qin, Yejun
Li, Yintao
SULT1E1 inhibits cell proliferation and invasion by activating PPARγ in breast cancer
title SULT1E1 inhibits cell proliferation and invasion by activating PPARγ in breast cancer
title_full SULT1E1 inhibits cell proliferation and invasion by activating PPARγ in breast cancer
title_fullStr SULT1E1 inhibits cell proliferation and invasion by activating PPARγ in breast cancer
title_full_unstemmed SULT1E1 inhibits cell proliferation and invasion by activating PPARγ in breast cancer
title_short SULT1E1 inhibits cell proliferation and invasion by activating PPARγ in breast cancer
title_sort sult1e1 inhibits cell proliferation and invasion by activating pparγ in breast cancer
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868175/
https://www.ncbi.nlm.nih.gov/pubmed/29581787
http://dx.doi.org/10.7150/jca.23596
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