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Present developments in reaching an international consensus for a model-based approach to particle beam therapy

Particle beam therapy (PBT), including proton and carbon ion therapy, is an emerging innovative treatment for cancer patients. Due to the high cost of and limited access to treatment, meticulous selection of patients who would benefit most from PBT, when compared with standard X-ray therapy (XRT), i...

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Autores principales: Prayongrat, Anussara, Umegaki, Kikuo, van der Schaaf, Arjen, Koong, Albert C, Lin, Steven H, Whitaker, Thomas, McNutt, Todd, Matsufuji, Naruhiro, Graves, Edward, Mizuta, Masahiko, Ogawa, Kazuhiko, Date, Hiroyuki, Moriwaki, Kensuke, Ito, Yoichi M, Kobashi, Keiji, Dekura, Yasuhiro, Shimizu, Shinichi, Shirato, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868183/
https://www.ncbi.nlm.nih.gov/pubmed/29529229
http://dx.doi.org/10.1093/jrr/rry008
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author Prayongrat, Anussara
Umegaki, Kikuo
van der Schaaf, Arjen
Koong, Albert C
Lin, Steven H
Whitaker, Thomas
McNutt, Todd
Matsufuji, Naruhiro
Graves, Edward
Mizuta, Masahiko
Ogawa, Kazuhiko
Date, Hiroyuki
Moriwaki, Kensuke
Ito, Yoichi M
Kobashi, Keiji
Dekura, Yasuhiro
Shimizu, Shinichi
Shirato, Hiroki
author_facet Prayongrat, Anussara
Umegaki, Kikuo
van der Schaaf, Arjen
Koong, Albert C
Lin, Steven H
Whitaker, Thomas
McNutt, Todd
Matsufuji, Naruhiro
Graves, Edward
Mizuta, Masahiko
Ogawa, Kazuhiko
Date, Hiroyuki
Moriwaki, Kensuke
Ito, Yoichi M
Kobashi, Keiji
Dekura, Yasuhiro
Shimizu, Shinichi
Shirato, Hiroki
author_sort Prayongrat, Anussara
collection PubMed
description Particle beam therapy (PBT), including proton and carbon ion therapy, is an emerging innovative treatment for cancer patients. Due to the high cost of and limited access to treatment, meticulous selection of patients who would benefit most from PBT, when compared with standard X-ray therapy (XRT), is necessary. Due to the cost and labor involved in randomized controlled trials, the model-based approach (MBA) is used as an alternative means of establishing scientific evidence in medicine, and it can be improved continuously. Good databases and reasonable models are crucial for the reliability of this approach. The tumor control probability and normal tissue complication probability models are good illustrations of the advantages of PBT, but pre-existing NTCP models have been derived from historical patient treatments from the XRT era. This highlights the necessity of prospectively analyzing specific treatment-related toxicities in order to develop PBT-compatible models. An international consensus has been reached at the Global Institution for Collaborative Research and Education (GI-CoRE) joint symposium, concluding that a systematically developed model is required for model accuracy and performance. Six important steps that need to be observed in these considerations include patient selection, treatment planning, beam delivery, dose verification, response assessment, and data analysis. Advanced technologies in radiotherapy and computer science can be integrated to improve the efficacy of a treatment. Model validation and appropriately defined thresholds in a cost-effectiveness centered manner, together with quality assurance in the treatment planning, have to be achieved prior to clinical implementation.
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spelling pubmed-58681832018-03-29 Present developments in reaching an international consensus for a model-based approach to particle beam therapy Prayongrat, Anussara Umegaki, Kikuo van der Schaaf, Arjen Koong, Albert C Lin, Steven H Whitaker, Thomas McNutt, Todd Matsufuji, Naruhiro Graves, Edward Mizuta, Masahiko Ogawa, Kazuhiko Date, Hiroyuki Moriwaki, Kensuke Ito, Yoichi M Kobashi, Keiji Dekura, Yasuhiro Shimizu, Shinichi Shirato, Hiroki J Radiat Res Supplement Paper Particle beam therapy (PBT), including proton and carbon ion therapy, is an emerging innovative treatment for cancer patients. Due to the high cost of and limited access to treatment, meticulous selection of patients who would benefit most from PBT, when compared with standard X-ray therapy (XRT), is necessary. Due to the cost and labor involved in randomized controlled trials, the model-based approach (MBA) is used as an alternative means of establishing scientific evidence in medicine, and it can be improved continuously. Good databases and reasonable models are crucial for the reliability of this approach. The tumor control probability and normal tissue complication probability models are good illustrations of the advantages of PBT, but pre-existing NTCP models have been derived from historical patient treatments from the XRT era. This highlights the necessity of prospectively analyzing specific treatment-related toxicities in order to develop PBT-compatible models. An international consensus has been reached at the Global Institution for Collaborative Research and Education (GI-CoRE) joint symposium, concluding that a systematically developed model is required for model accuracy and performance. Six important steps that need to be observed in these considerations include patient selection, treatment planning, beam delivery, dose verification, response assessment, and data analysis. Advanced technologies in radiotherapy and computer science can be integrated to improve the efficacy of a treatment. Model validation and appropriately defined thresholds in a cost-effectiveness centered manner, together with quality assurance in the treatment planning, have to be achieved prior to clinical implementation. Oxford University Press 2018-03 2018-02-24 /pmc/articles/PMC5868183/ /pubmed/29529229 http://dx.doi.org/10.1093/jrr/rry008 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Radiation Oncology. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Supplement Paper
Prayongrat, Anussara
Umegaki, Kikuo
van der Schaaf, Arjen
Koong, Albert C
Lin, Steven H
Whitaker, Thomas
McNutt, Todd
Matsufuji, Naruhiro
Graves, Edward
Mizuta, Masahiko
Ogawa, Kazuhiko
Date, Hiroyuki
Moriwaki, Kensuke
Ito, Yoichi M
Kobashi, Keiji
Dekura, Yasuhiro
Shimizu, Shinichi
Shirato, Hiroki
Present developments in reaching an international consensus for a model-based approach to particle beam therapy
title Present developments in reaching an international consensus for a model-based approach to particle beam therapy
title_full Present developments in reaching an international consensus for a model-based approach to particle beam therapy
title_fullStr Present developments in reaching an international consensus for a model-based approach to particle beam therapy
title_full_unstemmed Present developments in reaching an international consensus for a model-based approach to particle beam therapy
title_short Present developments in reaching an international consensus for a model-based approach to particle beam therapy
title_sort present developments in reaching an international consensus for a model-based approach to particle beam therapy
topic Supplement Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868183/
https://www.ncbi.nlm.nih.gov/pubmed/29529229
http://dx.doi.org/10.1093/jrr/rry008
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