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Selection of external beam radiotherapy approaches for precise and accurate cancer treatment

Physically precise external-beam radiotherapy (EBRT) technologies may not translate to the best outcome in individual patients. On the other hand, clinical considerations alone are often insufficient to guide the selection of a specific EBRT approach in patients. We examine the ways in which to comp...

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Detalles Bibliográficos
Autores principales: Shirato, Hiroki, Le, Quynh-Thu, Kobashi, Keiji, Prayongrat, Anussara, Takao, Seishin, Shimizu, Shinichi, Giaccia, Amato, Xing, Lei, Umegaki, Kikuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868193/
https://www.ncbi.nlm.nih.gov/pubmed/29373709
http://dx.doi.org/10.1093/jrr/rrx092
Descripción
Sumario:Physically precise external-beam radiotherapy (EBRT) technologies may not translate to the best outcome in individual patients. On the other hand, clinical considerations alone are often insufficient to guide the selection of a specific EBRT approach in patients. We examine the ways in which to compare different EBRT approaches based on physical, biological and clinical considerations, and how they can be enhanced with the addition of biophysical models and machine-learning strategies. The process of selecting an EBRT modality is expected to improve in tandem with knowledge-based treatment planning.