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Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer

OBJECTIVE: Desmoplasia and hypovascularity are thought to impede drug delivery in pancreatic ductal adenocarcinoma (PDAC). However, stromal depletion approaches have failed to show clinical responses in patients. Here, we aimed to revisit the role of the tumour microenvironment as a physical barrier...

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Detalles Bibliográficos
Autores principales:	Hessmann, E, Patzak, M S, Klein, L, Chen, N, Kari, V, Ramu, I, Bapiro, T E, Frese, K K, Gopinathan, A, Richards, F M, Jodrell, D I, Verbeke, C, Li, X, Heuchel, R, Löhr, J M, Johnsen, S A, Gress, T M, Ellenrieder, V, Neesse, A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2018
Materias:	Pancreas
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868285/ https://www.ncbi.nlm.nih.gov/pubmed/28077438 http://dx.doi.org/10.1136/gutjnl-2016-311954

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