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Downregulation of SLC7A7 Triggers an Inflammatory Phenotype in Human Macrophages and Airway Epithelial Cells

Lysinuric protein intolerance (LPI) is a recessively inherited aminoaciduria caused by mutations of SLC7A7, the gene encoding y+LAT1 light chain of system y(+)L for cationic amino acid transport. The pathogenesis of LPI is still unknown. In this study, we have utilized a gene silencing approach in m...

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Detalles Bibliográficos
Autores principales:	Rotoli, Bianca Maria, Barilli, Amelia, Visigalli, Rossana, Ingoglia, Filippo, Milioli, Marco, Di Lascia, Maria, Riccardi, Benedetta, Puccini, Paola, Dall’Asta, Valeria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868322/ https://www.ncbi.nlm.nih.gov/pubmed/29616026 http://dx.doi.org/10.3389/fimmu.2018.00508

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