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Epilepsy an Update on Disease Mechanisms: The Potential Role of MicroRNAs

So far, research on epilepsy mechanisms has been designed mainly using animal models and tracking down molecular mechanisms underlying seizures in that model. While this approach is clearly valuable, it can be questioned if it is the best possible. One attractive alternative approach may stem from t...

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Detalles Bibliográficos
Autor principal: Simonato, Michele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868323/
https://www.ncbi.nlm.nih.gov/pubmed/29615968
http://dx.doi.org/10.3389/fneur.2018.00176
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author Simonato, Michele
author_facet Simonato, Michele
author_sort Simonato, Michele
collection PubMed
description So far, research on epilepsy mechanisms has been designed mainly using animal models and tracking down molecular mechanisms underlying seizures in that model. While this approach is clearly valuable, it can be questioned if it is the best possible. One attractive alternative approach may stem from the consideration of epilepsy as a complex disease of a very complex organ, the brain. This short review summarizes data from analyses of the alterations in expression of microRNAs and their target messenger RNAs in a specific brain subregion, the dentate gyrus of the hippocampus, in three experimental models of lesional epilepsy. The findings are discussed within the conceptual framework of complex systems.
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spelling pubmed-58683232018-04-03 Epilepsy an Update on Disease Mechanisms: The Potential Role of MicroRNAs Simonato, Michele Front Neurol Neuroscience So far, research on epilepsy mechanisms has been designed mainly using animal models and tracking down molecular mechanisms underlying seizures in that model. While this approach is clearly valuable, it can be questioned if it is the best possible. One attractive alternative approach may stem from the consideration of epilepsy as a complex disease of a very complex organ, the brain. This short review summarizes data from analyses of the alterations in expression of microRNAs and their target messenger RNAs in a specific brain subregion, the dentate gyrus of the hippocampus, in three experimental models of lesional epilepsy. The findings are discussed within the conceptual framework of complex systems. Frontiers Media S.A. 2018-03-19 /pmc/articles/PMC5868323/ /pubmed/29615968 http://dx.doi.org/10.3389/fneur.2018.00176 Text en Copyright © 2018 Simonato. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Simonato, Michele
Epilepsy an Update on Disease Mechanisms: The Potential Role of MicroRNAs
title Epilepsy an Update on Disease Mechanisms: The Potential Role of MicroRNAs
title_full Epilepsy an Update on Disease Mechanisms: The Potential Role of MicroRNAs
title_fullStr Epilepsy an Update on Disease Mechanisms: The Potential Role of MicroRNAs
title_full_unstemmed Epilepsy an Update on Disease Mechanisms: The Potential Role of MicroRNAs
title_short Epilepsy an Update on Disease Mechanisms: The Potential Role of MicroRNAs
title_sort epilepsy an update on disease mechanisms: the potential role of micrornas
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868323/
https://www.ncbi.nlm.nih.gov/pubmed/29615968
http://dx.doi.org/10.3389/fneur.2018.00176
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