Genetic Determinants of Circulating Estrogen Levels and Evidence of a Causal Effect of Estradiol on Bone Density in Men

CONTEXT: Serum estradiol (E2) and estrone (E1) levels exhibit substantial heritability. OBJECTIVE: To investigate the genetic regulation of serum E2 and E1 in men. DESIGN, SETTING, AND PARTICIPANTS: Genome-wide association study in 11,097 men of European origin from nine epidemiological cohorts. MAI...

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Detalles Bibliográficos
Autores principales: Eriksson, Anna L, Perry, John R B, Coviello, Andrea D, Delgado, Graciela E, Ferrucci, Luigi, Hoffman, Andrew R, Huhtaniemi, Ilpo T, Ikram, M Arfan, Karlsson, Magnus K, Kleber, Marcus E, Laughlin, Gail A, Liu, Yongmei, Lorentzon, Mattias, Lunetta, Kathryn L, Mellström, Dan, Murabito, Joanne M, Murray, Anna, Nethander, Maria, Nielson, Carrie M, Prokopenko, Inga, Pye, Stephen R, Raffel, Leslie J, Rivadeneira, Fernando, Srikanth, Priya, Stolk, Lisette, Teumer, Alexander, Travison, Thomas G, Uitterlinden, André G, Vaidya, Dhananjay, Vanderschueren, Dirk, Zmuda, Joseph M, März, Winfried, Orwoll, Eric S, Ouyang, Pamela, Vandenput, Liesbeth, Wu, Frederick C W, de Jong, Frank H, Bhasin, Shalender, Kiel, Douglas P, Ohlsson, Claes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Endocrine Society 2018
Materias:
Clinical Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868407/
https://www.ncbi.nlm.nih.gov/pubmed/29325096
http://dx.doi.org/10.1210/jc.2017-02060

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