Targeting DTL induces cell cycle arrest and senescence and suppresses cell growth and colony formation through TPX2 inhibition in human hepatocellular carcinoma cells

BACKGROUND: Hepatocellular carcinoma (HCC) has an increasing incidence and high mortality. Surgical operation is not a comprehensive strategy for liver cancer. Moreover, tolerating systemic chemotherapy is difficult for patients with HCC because hepatic function is often impaired due to underlying c...

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Detalles Bibliográficos
Autores principales: Chen, Yu-Chia, Chen, I-shu, Huang, Guan-Jin, Kang, Chi-hsiang, Wang, Kuo-Chiang, Tsao, Min-Jen, Pan, Hung-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868578/
https://www.ncbi.nlm.nih.gov/pubmed/29606879
http://dx.doi.org/10.2147/OTT.S147453

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