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Rucaparib: a novel PARP inhibitor for BRCA advanced ovarian cancer

Rucaparib is a potent small-molecule inhibitor of poly (ADP-ribose) polymerase (PARP) proteins (PARP-1, PARP-2 and PARP-3) that play an important role in repairing DNA damage and maintaining genomic stability. Tumors with mutations in BRCA1/2 or other homologous recombination deficiency (HRD) genes...

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Detalles Bibliográficos
Autores principales:	Colombo, Ilaria, Lheureux, Stephanie, Oza, Amit Manulal
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868608/ https://www.ncbi.nlm.nih.gov/pubmed/29606854 http://dx.doi.org/10.2147/DDDT.S130809

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