Cargando…

Can we define migraine patients with blood high-sensitivity C-reactive protein and galectin-3 levels in the emergency department?

INTRODUCTION: Migraine, the most widespread cause of headache in young adults, is a frequent reason for presentation to emergency departments. The aim of this study was to determine the diagnostic value of serum galectin-3 and high-sensitivity C-reactive protein (hsCRP) levels in migraine patients....

Descripción completa

Detalles Bibliográficos
Autores principales: Gürger, Mehtap, Atescelik, Metin, Yilmaz, Mustafa, Yildiz, Mustafa, Kalayci, Hatice, Kobat, Mehmet Ali, Demir, Caner Fevzi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868668/
https://www.ncbi.nlm.nih.gov/pubmed/29593803
http://dx.doi.org/10.5114/aoms.2016.60984
_version_ 1783309173120827392
author Gürger, Mehtap
Atescelik, Metin
Yilmaz, Mustafa
Yildiz, Mustafa
Kalayci, Hatice
Kobat, Mehmet Ali
Demir, Caner Fevzi
author_facet Gürger, Mehtap
Atescelik, Metin
Yilmaz, Mustafa
Yildiz, Mustafa
Kalayci, Hatice
Kobat, Mehmet Ali
Demir, Caner Fevzi
author_sort Gürger, Mehtap
collection PubMed
description INTRODUCTION: Migraine, the most widespread cause of headache in young adults, is a frequent reason for presentation to emergency departments. The aim of this study was to determine the diagnostic value of serum galectin-3 and high-sensitivity C-reactive protein (hsCRP) levels in migraine patients. MATERIAL AND METHODS: Serum galectin-3 and hsCRP levels were measured using enzyme-linked immunosorbent assay in 70 migraine patients and 70 healthy control subjects. RESULTS: The mean values of hsCRP and galectin-3 levels were significantly higher in the migraine group than those in the control group (1.67 ±0.49, 1.12 ±0.38 mg/l, p < 0.001; and 3.76 ±1.45, 2.05 ±0.29 ng/ml, p < 0.001, respectively). When the diagnostic values of the biomarkers were assessed in the migraine attack and control groups, the sensitivity and specificity of the test for hsCRP at the cut-off point of 1.32 mg/l were 70% and 73% (AUC = 0.805, 95% CI: 0.74–0.88, p < 0.001), and for galectin-3 at the cut-off point of 2.4 ng/ml, 89% and 90% (AUC = 0.97, 95% CI: 0.95–0.99, p < 0.001), respectively. CONCLUSIONS: This study showed the presence of a relation between high serum levels of hsCRP and galectin-3 in migraine patients. However, well-controlled, carefully executed longitudinal studies are required to confirm these findings.
format Online
Article
Text
id pubmed-5868668
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Termedia Publishing House
record_format MEDLINE/PubMed
spelling pubmed-58686682018-03-28 Can we define migraine patients with blood high-sensitivity C-reactive protein and galectin-3 levels in the emergency department? Gürger, Mehtap Atescelik, Metin Yilmaz, Mustafa Yildiz, Mustafa Kalayci, Hatice Kobat, Mehmet Ali Demir, Caner Fevzi Arch Med Sci Clinical Research INTRODUCTION: Migraine, the most widespread cause of headache in young adults, is a frequent reason for presentation to emergency departments. The aim of this study was to determine the diagnostic value of serum galectin-3 and high-sensitivity C-reactive protein (hsCRP) levels in migraine patients. MATERIAL AND METHODS: Serum galectin-3 and hsCRP levels were measured using enzyme-linked immunosorbent assay in 70 migraine patients and 70 healthy control subjects. RESULTS: The mean values of hsCRP and galectin-3 levels were significantly higher in the migraine group than those in the control group (1.67 ±0.49, 1.12 ±0.38 mg/l, p < 0.001; and 3.76 ±1.45, 2.05 ±0.29 ng/ml, p < 0.001, respectively). When the diagnostic values of the biomarkers were assessed in the migraine attack and control groups, the sensitivity and specificity of the test for hsCRP at the cut-off point of 1.32 mg/l were 70% and 73% (AUC = 0.805, 95% CI: 0.74–0.88, p < 0.001), and for galectin-3 at the cut-off point of 2.4 ng/ml, 89% and 90% (AUC = 0.97, 95% CI: 0.95–0.99, p < 0.001), respectively. CONCLUSIONS: This study showed the presence of a relation between high serum levels of hsCRP and galectin-3 in migraine patients. However, well-controlled, carefully executed longitudinal studies are required to confirm these findings. Termedia Publishing House 2016-06-30 2018-03 /pmc/articles/PMC5868668/ /pubmed/29593803 http://dx.doi.org/10.5114/aoms.2016.60984 Text en Copyright: © 2016 Termedia & Banach http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.
spellingShingle Clinical Research
Gürger, Mehtap
Atescelik, Metin
Yilmaz, Mustafa
Yildiz, Mustafa
Kalayci, Hatice
Kobat, Mehmet Ali
Demir, Caner Fevzi
Can we define migraine patients with blood high-sensitivity C-reactive protein and galectin-3 levels in the emergency department?
title Can we define migraine patients with blood high-sensitivity C-reactive protein and galectin-3 levels in the emergency department?
title_full Can we define migraine patients with blood high-sensitivity C-reactive protein and galectin-3 levels in the emergency department?
title_fullStr Can we define migraine patients with blood high-sensitivity C-reactive protein and galectin-3 levels in the emergency department?
title_full_unstemmed Can we define migraine patients with blood high-sensitivity C-reactive protein and galectin-3 levels in the emergency department?
title_short Can we define migraine patients with blood high-sensitivity C-reactive protein and galectin-3 levels in the emergency department?
title_sort can we define migraine patients with blood high-sensitivity c-reactive protein and galectin-3 levels in the emergency department?
topic Clinical Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868668/
https://www.ncbi.nlm.nih.gov/pubmed/29593803
http://dx.doi.org/10.5114/aoms.2016.60984
work_keys_str_mv AT gurgermehtap canwedefinemigrainepatientswithbloodhighsensitivitycreactiveproteinandgalectin3levelsintheemergencydepartment
AT atescelikmetin canwedefinemigrainepatientswithbloodhighsensitivitycreactiveproteinandgalectin3levelsintheemergencydepartment
AT yilmazmustafa canwedefinemigrainepatientswithbloodhighsensitivitycreactiveproteinandgalectin3levelsintheemergencydepartment
AT yildizmustafa canwedefinemigrainepatientswithbloodhighsensitivitycreactiveproteinandgalectin3levelsintheemergencydepartment
AT kalaycihatice canwedefinemigrainepatientswithbloodhighsensitivitycreactiveproteinandgalectin3levelsintheemergencydepartment
AT kobatmehmetali canwedefinemigrainepatientswithbloodhighsensitivitycreactiveproteinandgalectin3levelsintheemergencydepartment
AT demircanerfevzi canwedefinemigrainepatientswithbloodhighsensitivitycreactiveproteinandgalectin3levelsintheemergencydepartment