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Can we define migraine patients with blood high-sensitivity C-reactive protein and galectin-3 levels in the emergency department?
INTRODUCTION: Migraine, the most widespread cause of headache in young adults, is a frequent reason for presentation to emergency departments. The aim of this study was to determine the diagnostic value of serum galectin-3 and high-sensitivity C-reactive protein (hsCRP) levels in migraine patients....
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868668/ https://www.ncbi.nlm.nih.gov/pubmed/29593803 http://dx.doi.org/10.5114/aoms.2016.60984 |
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author | Gürger, Mehtap Atescelik, Metin Yilmaz, Mustafa Yildiz, Mustafa Kalayci, Hatice Kobat, Mehmet Ali Demir, Caner Fevzi |
author_facet | Gürger, Mehtap Atescelik, Metin Yilmaz, Mustafa Yildiz, Mustafa Kalayci, Hatice Kobat, Mehmet Ali Demir, Caner Fevzi |
author_sort | Gürger, Mehtap |
collection | PubMed |
description | INTRODUCTION: Migraine, the most widespread cause of headache in young adults, is a frequent reason for presentation to emergency departments. The aim of this study was to determine the diagnostic value of serum galectin-3 and high-sensitivity C-reactive protein (hsCRP) levels in migraine patients. MATERIAL AND METHODS: Serum galectin-3 and hsCRP levels were measured using enzyme-linked immunosorbent assay in 70 migraine patients and 70 healthy control subjects. RESULTS: The mean values of hsCRP and galectin-3 levels were significantly higher in the migraine group than those in the control group (1.67 ±0.49, 1.12 ±0.38 mg/l, p < 0.001; and 3.76 ±1.45, 2.05 ±0.29 ng/ml, p < 0.001, respectively). When the diagnostic values of the biomarkers were assessed in the migraine attack and control groups, the sensitivity and specificity of the test for hsCRP at the cut-off point of 1.32 mg/l were 70% and 73% (AUC = 0.805, 95% CI: 0.74–0.88, p < 0.001), and for galectin-3 at the cut-off point of 2.4 ng/ml, 89% and 90% (AUC = 0.97, 95% CI: 0.95–0.99, p < 0.001), respectively. CONCLUSIONS: This study showed the presence of a relation between high serum levels of hsCRP and galectin-3 in migraine patients. However, well-controlled, carefully executed longitudinal studies are required to confirm these findings. |
format | Online Article Text |
id | pubmed-5868668 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-58686682018-03-28 Can we define migraine patients with blood high-sensitivity C-reactive protein and galectin-3 levels in the emergency department? Gürger, Mehtap Atescelik, Metin Yilmaz, Mustafa Yildiz, Mustafa Kalayci, Hatice Kobat, Mehmet Ali Demir, Caner Fevzi Arch Med Sci Clinical Research INTRODUCTION: Migraine, the most widespread cause of headache in young adults, is a frequent reason for presentation to emergency departments. The aim of this study was to determine the diagnostic value of serum galectin-3 and high-sensitivity C-reactive protein (hsCRP) levels in migraine patients. MATERIAL AND METHODS: Serum galectin-3 and hsCRP levels were measured using enzyme-linked immunosorbent assay in 70 migraine patients and 70 healthy control subjects. RESULTS: The mean values of hsCRP and galectin-3 levels were significantly higher in the migraine group than those in the control group (1.67 ±0.49, 1.12 ±0.38 mg/l, p < 0.001; and 3.76 ±1.45, 2.05 ±0.29 ng/ml, p < 0.001, respectively). When the diagnostic values of the biomarkers were assessed in the migraine attack and control groups, the sensitivity and specificity of the test for hsCRP at the cut-off point of 1.32 mg/l were 70% and 73% (AUC = 0.805, 95% CI: 0.74–0.88, p < 0.001), and for galectin-3 at the cut-off point of 2.4 ng/ml, 89% and 90% (AUC = 0.97, 95% CI: 0.95–0.99, p < 0.001), respectively. CONCLUSIONS: This study showed the presence of a relation between high serum levels of hsCRP and galectin-3 in migraine patients. However, well-controlled, carefully executed longitudinal studies are required to confirm these findings. Termedia Publishing House 2016-06-30 2018-03 /pmc/articles/PMC5868668/ /pubmed/29593803 http://dx.doi.org/10.5114/aoms.2016.60984 Text en Copyright: © 2016 Termedia & Banach http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Clinical Research Gürger, Mehtap Atescelik, Metin Yilmaz, Mustafa Yildiz, Mustafa Kalayci, Hatice Kobat, Mehmet Ali Demir, Caner Fevzi Can we define migraine patients with blood high-sensitivity C-reactive protein and galectin-3 levels in the emergency department? |
title | Can we define migraine patients with blood high-sensitivity C-reactive protein and galectin-3 levels in the emergency department? |
title_full | Can we define migraine patients with blood high-sensitivity C-reactive protein and galectin-3 levels in the emergency department? |
title_fullStr | Can we define migraine patients with blood high-sensitivity C-reactive protein and galectin-3 levels in the emergency department? |
title_full_unstemmed | Can we define migraine patients with blood high-sensitivity C-reactive protein and galectin-3 levels in the emergency department? |
title_short | Can we define migraine patients with blood high-sensitivity C-reactive protein and galectin-3 levels in the emergency department? |
title_sort | can we define migraine patients with blood high-sensitivity c-reactive protein and galectin-3 levels in the emergency department? |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868668/ https://www.ncbi.nlm.nih.gov/pubmed/29593803 http://dx.doi.org/10.5114/aoms.2016.60984 |
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