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Neural processing of food and emotional stimuli in adolescent and adult anorexia nervosa patients

BACKGROUND: A constant preoccupation with food and restrictive eating are main symptoms of anorexia nervosa (AN). Imaging studies revealed aberrant neural activation patterns in brain regions processing hedonic and reward reactions as well as–potentially aversive–emotions. An imbalance between so ca...

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Autores principales: Horndasch, Stefanie, Roesch, Julie, Forster, Clemens, Dörfler, Arnd, Lindsiepe, Silja, Heinrich, Hartmut, Graap, Holmer, Moll, Gunther H., Kratz, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868769/
https://www.ncbi.nlm.nih.gov/pubmed/29579064
http://dx.doi.org/10.1371/journal.pone.0191059
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author Horndasch, Stefanie
Roesch, Julie
Forster, Clemens
Dörfler, Arnd
Lindsiepe, Silja
Heinrich, Hartmut
Graap, Holmer
Moll, Gunther H.
Kratz, Oliver
author_facet Horndasch, Stefanie
Roesch, Julie
Forster, Clemens
Dörfler, Arnd
Lindsiepe, Silja
Heinrich, Hartmut
Graap, Holmer
Moll, Gunther H.
Kratz, Oliver
author_sort Horndasch, Stefanie
collection PubMed
description BACKGROUND: A constant preoccupation with food and restrictive eating are main symptoms of anorexia nervosa (AN). Imaging studies revealed aberrant neural activation patterns in brain regions processing hedonic and reward reactions as well as–potentially aversive–emotions. An imbalance between so called “bottom-up” and “top-down” control areas is discussed. The present study is focusing on neural processing of disease-specific food stimuli and emotional stimuli and its developmental course in adolescent and adult AN patients and could offer new insight into differential mechanisms underlying shorter or more chronic disease. METHODS: 33 adolescents aged 12–18 years (15 AN patients, 18 control participants) and 32 adult women (16 AN patients, 16 control participants) underwent functional magnetic resonance imaging (fMRI, 3T high-field scanner) while watching pictures of high and low-calorie food and affective stimuli. Afterwards, they rated subjective valence of each picture. FMRI data analysis was performed using a region of interest based approach. RESULTS: Pictures of high-calorie food items were rated more negatively by AN patients. Differences in activation between patients and controls were found in “bottom up” and “top down” control areas for food stimuli and in several emotion processing regions for affective stimuli which were more pronounced in adolescents than in adults. CONCLUSION: A differential pattern was seen for food stimuli compared to generally emotion eliciting stimuli. Adolescents with AN show reduced processing of affective stimuli and enhanced activation of regions involved in “bottom up” reward processing and “top down” control as well as the insula with regard to food stimuli with a focus on brain regions which underlie changes during adolescent development. In adults less clear and less specific activation differences were present, pointing towards a high impact that regions undergoing maturation might have on AN symptoms.
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spelling pubmed-58687692018-04-06 Neural processing of food and emotional stimuli in adolescent and adult anorexia nervosa patients Horndasch, Stefanie Roesch, Julie Forster, Clemens Dörfler, Arnd Lindsiepe, Silja Heinrich, Hartmut Graap, Holmer Moll, Gunther H. Kratz, Oliver PLoS One Research Article BACKGROUND: A constant preoccupation with food and restrictive eating are main symptoms of anorexia nervosa (AN). Imaging studies revealed aberrant neural activation patterns in brain regions processing hedonic and reward reactions as well as–potentially aversive–emotions. An imbalance between so called “bottom-up” and “top-down” control areas is discussed. The present study is focusing on neural processing of disease-specific food stimuli and emotional stimuli and its developmental course in adolescent and adult AN patients and could offer new insight into differential mechanisms underlying shorter or more chronic disease. METHODS: 33 adolescents aged 12–18 years (15 AN patients, 18 control participants) and 32 adult women (16 AN patients, 16 control participants) underwent functional magnetic resonance imaging (fMRI, 3T high-field scanner) while watching pictures of high and low-calorie food and affective stimuli. Afterwards, they rated subjective valence of each picture. FMRI data analysis was performed using a region of interest based approach. RESULTS: Pictures of high-calorie food items were rated more negatively by AN patients. Differences in activation between patients and controls were found in “bottom up” and “top down” control areas for food stimuli and in several emotion processing regions for affective stimuli which were more pronounced in adolescents than in adults. CONCLUSION: A differential pattern was seen for food stimuli compared to generally emotion eliciting stimuli. Adolescents with AN show reduced processing of affective stimuli and enhanced activation of regions involved in “bottom up” reward processing and “top down” control as well as the insula with regard to food stimuli with a focus on brain regions which underlie changes during adolescent development. In adults less clear and less specific activation differences were present, pointing towards a high impact that regions undergoing maturation might have on AN symptoms. Public Library of Science 2018-03-26 /pmc/articles/PMC5868769/ /pubmed/29579064 http://dx.doi.org/10.1371/journal.pone.0191059 Text en © 2018 Horndasch et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Horndasch, Stefanie
Roesch, Julie
Forster, Clemens
Dörfler, Arnd
Lindsiepe, Silja
Heinrich, Hartmut
Graap, Holmer
Moll, Gunther H.
Kratz, Oliver
Neural processing of food and emotional stimuli in adolescent and adult anorexia nervosa patients
title Neural processing of food and emotional stimuli in adolescent and adult anorexia nervosa patients
title_full Neural processing of food and emotional stimuli in adolescent and adult anorexia nervosa patients
title_fullStr Neural processing of food and emotional stimuli in adolescent and adult anorexia nervosa patients
title_full_unstemmed Neural processing of food and emotional stimuli in adolescent and adult anorexia nervosa patients
title_short Neural processing of food and emotional stimuli in adolescent and adult anorexia nervosa patients
title_sort neural processing of food and emotional stimuli in adolescent and adult anorexia nervosa patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868769/
https://www.ncbi.nlm.nih.gov/pubmed/29579064
http://dx.doi.org/10.1371/journal.pone.0191059
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