Effects of pharmacologic sclerostin inhibition or testosterone administration on soleus muscle atrophy in rodents after spinal cord injury

Sclerostin is a circulating osteocyte-derived glycoprotein that negatively regulates Wnt-signaling after binding the LRP5/LRP6 co-receptors. Pharmacologic sclerostin inhibition produces bone anabolic effects after spinal cord injury (SCI), however, the effects of sclerostin-antibody (Scl-Ab) on musc...

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Detalles Bibliográficos
Autores principales: Phillips, Ean G., Beggs, Luke A., Ye, Fan, Conover, Christine F., Beck, Darren T., Otzel, Dana M., Ghosh, Payal, Bassit, Anna C. F., Borst, Stephen E., Yarrow, Joshua F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868788/
https://www.ncbi.nlm.nih.gov/pubmed/29579075
http://dx.doi.org/10.1371/journal.pone.0194440

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868788/
https://www.ncbi.nlm.nih.gov/pubmed/29579075
http://dx.doi.org/10.1371/journal.pone.0194440

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