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Genetics in TNF-TNFR pathway: A complex network causing spondyloarthritis and conditioning response to anti-TNFα therapy

OBJECTIVES: We investigated whether polymorphisms (SNPs) in the promoter region of TNFA, or in the autoinflammatory TNFRSF1A and MEFV genes, concur with HLA-B27 in enhancing the risk of Spondyloarthritis (SpA) and/or in predicting the response to anti-TNFα treatment. METHODS: 373 controls and 137 Sp...

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Detalles Bibliográficos
Autores principales:	Aita, Ada, Basso, Daniela, Ramonda, Roberta, Moz, Stefania, Lorenzin, Mariagrazia, Navaglia, Filippo, Zambon, Carlo-Federico, Padoan, Andrea, Plebani, Mario, Punzi, Leonardo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868803/ https://www.ncbi.nlm.nih.gov/pubmed/29579081 http://dx.doi.org/10.1371/journal.pone.0194693

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