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Clinical characteristics and patient-reported outcomes in patients with inadequately controlled rheumatoid arthritis despite ongoing treatment
BACKGROUND: Despite the wide array of treatments available for rheumatoid arthritis (RA), some patients continue to report unmet clinical needs. We investigated the extent of inadequate disease control in patients with RA. METHODS: Data were drawn from the Adelphi 2014 RA Disease-Specific Program in...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BMJ Publishing Group
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869220/ https://www.ncbi.nlm.nih.gov/pubmed/29593881 http://dx.doi.org/10.1136/rmdopen-2017-000615 |
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author | Taylor, Peter C Alten, Rieke Gomez-Reino, Juan J Caporali, Roberto Bertin, Philippe Sullivan, Emma Wood, Robert Piercy, James Vasilescu, Radu Spurden, Dean Alvir, Jose Tarallo, Miriam |
author_facet | Taylor, Peter C Alten, Rieke Gomez-Reino, Juan J Caporali, Roberto Bertin, Philippe Sullivan, Emma Wood, Robert Piercy, James Vasilescu, Radu Spurden, Dean Alvir, Jose Tarallo, Miriam |
author_sort | Taylor, Peter C |
collection | PubMed |
description | BACKGROUND: Despite the wide array of treatments available for rheumatoid arthritis (RA), some patients continue to report unmet clinical needs. We investigated the extent of inadequate disease control in patients with RA. METHODS: Data were drawn from the Adelphi 2014 RA Disease-Specific Program in France, Germany, Italy, Spain and the UK. Rheumatologists provided patient demographics, comorbidities, satisfaction with RA control and other clinical details. Patients reported their level of satisfaction and completed the EuroQoL 5-Dimensions Health Questionnaire and Work Productivity and Activity Impairment Questionnaire. Patients had been on their current therapy ≥3 months and had 28-joint disease activity scores (DAS28) reported. Adequately controlled (DAS28 ≤3.2) and inadequately controlled (DAS28 >3.2) patient cohorts were compared using univariate tests. RESULTS: Of 1147 patients, 74% were women, the mean age was 52 years and the mean time since RA diagnosis was 7 years. Twenty-seven percent of patients had inadequately controlled RA, whereas 73% had adequately controlled RA. Inadequately controlled patients were more affected clinically versus adequately controlled patients; 69% vs 13% had moderate/severe RA, the current level of pain was 4.6 vs 2.3, and 67% vs 41% experienced flares, respectively (all p<0.0001). Inadequately controlled patients had higher rates of depression (16% vs 5%; p<0.0001), worse health state, greater work and activity impairment, and lower satisfaction rates among the patients and their physicians than the adequately controlled cohort. CONCLUSION: RA was insufficiently controlled in over a quarter of patients despite their current therapy and this had a negative impact on the patients. |
format | Online Article Text |
id | pubmed-5869220 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-58692202018-03-28 Clinical characteristics and patient-reported outcomes in patients with inadequately controlled rheumatoid arthritis despite ongoing treatment Taylor, Peter C Alten, Rieke Gomez-Reino, Juan J Caporali, Roberto Bertin, Philippe Sullivan, Emma Wood, Robert Piercy, James Vasilescu, Radu Spurden, Dean Alvir, Jose Tarallo, Miriam RMD Open Rheumatoid Arthritis BACKGROUND: Despite the wide array of treatments available for rheumatoid arthritis (RA), some patients continue to report unmet clinical needs. We investigated the extent of inadequate disease control in patients with RA. METHODS: Data were drawn from the Adelphi 2014 RA Disease-Specific Program in France, Germany, Italy, Spain and the UK. Rheumatologists provided patient demographics, comorbidities, satisfaction with RA control and other clinical details. Patients reported their level of satisfaction and completed the EuroQoL 5-Dimensions Health Questionnaire and Work Productivity and Activity Impairment Questionnaire. Patients had been on their current therapy ≥3 months and had 28-joint disease activity scores (DAS28) reported. Adequately controlled (DAS28 ≤3.2) and inadequately controlled (DAS28 >3.2) patient cohorts were compared using univariate tests. RESULTS: Of 1147 patients, 74% were women, the mean age was 52 years and the mean time since RA diagnosis was 7 years. Twenty-seven percent of patients had inadequately controlled RA, whereas 73% had adequately controlled RA. Inadequately controlled patients were more affected clinically versus adequately controlled patients; 69% vs 13% had moderate/severe RA, the current level of pain was 4.6 vs 2.3, and 67% vs 41% experienced flares, respectively (all p<0.0001). Inadequately controlled patients had higher rates of depression (16% vs 5%; p<0.0001), worse health state, greater work and activity impairment, and lower satisfaction rates among the patients and their physicians than the adequately controlled cohort. CONCLUSION: RA was insufficiently controlled in over a quarter of patients despite their current therapy and this had a negative impact on the patients. BMJ Publishing Group 2018-03-17 /pmc/articles/PMC5869220/ /pubmed/29593881 http://dx.doi.org/10.1136/rmdopen-2017-000615 Text en © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted. This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
spellingShingle | Rheumatoid Arthritis Taylor, Peter C Alten, Rieke Gomez-Reino, Juan J Caporali, Roberto Bertin, Philippe Sullivan, Emma Wood, Robert Piercy, James Vasilescu, Radu Spurden, Dean Alvir, Jose Tarallo, Miriam Clinical characteristics and patient-reported outcomes in patients with inadequately controlled rheumatoid arthritis despite ongoing treatment |
title | Clinical characteristics and patient-reported outcomes in patients with inadequately controlled rheumatoid arthritis despite ongoing treatment |
title_full | Clinical characteristics and patient-reported outcomes in patients with inadequately controlled rheumatoid arthritis despite ongoing treatment |
title_fullStr | Clinical characteristics and patient-reported outcomes in patients with inadequately controlled rheumatoid arthritis despite ongoing treatment |
title_full_unstemmed | Clinical characteristics and patient-reported outcomes in patients with inadequately controlled rheumatoid arthritis despite ongoing treatment |
title_short | Clinical characteristics and patient-reported outcomes in patients with inadequately controlled rheumatoid arthritis despite ongoing treatment |
title_sort | clinical characteristics and patient-reported outcomes in patients with inadequately controlled rheumatoid arthritis despite ongoing treatment |
topic | Rheumatoid Arthritis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869220/ https://www.ncbi.nlm.nih.gov/pubmed/29593881 http://dx.doi.org/10.1136/rmdopen-2017-000615 |
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