Animal models for filovirus infections

The family Filoviridae, which includes the genera Marburgvirus and Ebolavirus, contains some of the most pathogenic viruses in humans and non-human primates (NHPs), causing severe hemorrhagic fevers with high fatality rates. Small animal models against filoviruses using mice, guinea pigs, hamsters,...

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Detalles Bibliográficos
Autores principales: Siragam, Vinayakumar, Wong, Gary, Qiu, Xiang-Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Science Press 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869237/
https://www.ncbi.nlm.nih.gov/pubmed/29511141
http://dx.doi.org/10.24272/j.issn.2095-8137.2017.053
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author Siragam, Vinayakumar
Wong, Gary
Qiu, Xiang-Guo
author_facet Siragam, Vinayakumar
Wong, Gary
Qiu, Xiang-Guo
author_sort Siragam, Vinayakumar
collection PubMed
description The family Filoviridae, which includes the genera Marburgvirus and Ebolavirus, contains some of the most pathogenic viruses in humans and non-human primates (NHPs), causing severe hemorrhagic fevers with high fatality rates. Small animal models against filoviruses using mice, guinea pigs, hamsters, and ferrets have been developed with the goal of screening candidate vaccines and antivirals, before testing in the gold standard NHP models. In this review, we summarize the different animal models used to understand filovirus pathogenesis, and discuss the advantages and disadvantages of each model with respect to filovirus disease research.
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spelling pubmed-58692372018-04-12 Animal models for filovirus infections Siragam, Vinayakumar Wong, Gary Qiu, Xiang-Guo Zool Res Review The family Filoviridae, which includes the genera Marburgvirus and Ebolavirus, contains some of the most pathogenic viruses in humans and non-human primates (NHPs), causing severe hemorrhagic fevers with high fatality rates. Small animal models against filoviruses using mice, guinea pigs, hamsters, and ferrets have been developed with the goal of screening candidate vaccines and antivirals, before testing in the gold standard NHP models. In this review, we summarize the different animal models used to understand filovirus pathogenesis, and discuss the advantages and disadvantages of each model with respect to filovirus disease research. Science Press 2018-02-09 2018-01-18 /pmc/articles/PMC5869237/ /pubmed/29511141 http://dx.doi.org/10.24272/j.issn.2095-8137.2017.053 Text en © 2018. Editorial Office of Zoological Research, Kunming Institute of Zoology, Chinese Academy of Sciences http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Siragam, Vinayakumar
Wong, Gary
Qiu, Xiang-Guo
Animal models for filovirus infections
title Animal models for filovirus infections
title_full Animal models for filovirus infections
title_fullStr Animal models for filovirus infections
title_full_unstemmed Animal models for filovirus infections
title_short Animal models for filovirus infections
title_sort animal models for filovirus infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869237/
https://www.ncbi.nlm.nih.gov/pubmed/29511141
http://dx.doi.org/10.24272/j.issn.2095-8137.2017.053
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