Cargando…
Animal models for the study of hepatitis B virus infection
Even with an effective vaccine, an estimated 240 million people are chronically infected with hepatitis B virus (HBV) worldwide. Current antiviral therapies, including interferon and nucleot(s)ide analogues, rarely cure chronic hepatitis B. Animal models are very crucial for understanding the pathog...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Science Press
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869238/ https://www.ncbi.nlm.nih.gov/pubmed/29511142 http://dx.doi.org/10.24272/j.issn.2095-8137.2018.013 |
_version_ | 1783309247702892544 |
---|---|
author | Guo, Wei-Na Zhu, Bin Ai, Ling Yang, Dong-Liang Wang, Bao-Ju |
author_facet | Guo, Wei-Na Zhu, Bin Ai, Ling Yang, Dong-Liang Wang, Bao-Ju |
author_sort | Guo, Wei-Na |
collection | PubMed |
description | Even with an effective vaccine, an estimated 240 million people are chronically infected with hepatitis B virus (HBV) worldwide. Current antiviral therapies, including interferon and nucleot(s)ide analogues, rarely cure chronic hepatitis B. Animal models are very crucial for understanding the pathogenesis of chronic hepatitis B and developing new therapeutic drugs or strategies. HBV can only infect humans and chimpanzees, with the use of chimpanzees in HBV research strongly restricted. Thus, most advances in HBV research have been gained using mouse models with HBV replication or infection or models with HBV-related hepadnaviral infection. This review summarizes the animal models currently available for the study of HBV infection. |
format | Online Article Text |
id | pubmed-5869238 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Science Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-58692382018-04-12 Animal models for the study of hepatitis B virus infection Guo, Wei-Na Zhu, Bin Ai, Ling Yang, Dong-Liang Wang, Bao-Ju Zool Res Review Even with an effective vaccine, an estimated 240 million people are chronically infected with hepatitis B virus (HBV) worldwide. Current antiviral therapies, including interferon and nucleot(s)ide analogues, rarely cure chronic hepatitis B. Animal models are very crucial for understanding the pathogenesis of chronic hepatitis B and developing new therapeutic drugs or strategies. HBV can only infect humans and chimpanzees, with the use of chimpanzees in HBV research strongly restricted. Thus, most advances in HBV research have been gained using mouse models with HBV replication or infection or models with HBV-related hepadnaviral infection. This review summarizes the animal models currently available for the study of HBV infection. Science Press 2018-02-09 2018-01-18 /pmc/articles/PMC5869238/ /pubmed/29511142 http://dx.doi.org/10.24272/j.issn.2095-8137.2018.013 Text en © 2018. Editorial Office of Zoological Research, Kunming Institute of Zoology, Chinese Academy of Sciences http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Guo, Wei-Na Zhu, Bin Ai, Ling Yang, Dong-Liang Wang, Bao-Ju Animal models for the study of hepatitis B virus infection |
title | Animal models for the study of hepatitis B virus infection |
title_full | Animal models for the study of hepatitis B virus infection |
title_fullStr | Animal models for the study of hepatitis B virus infection |
title_full_unstemmed | Animal models for the study of hepatitis B virus infection |
title_short | Animal models for the study of hepatitis B virus infection |
title_sort | animal models for the study of hepatitis b virus infection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869238/ https://www.ncbi.nlm.nih.gov/pubmed/29511142 http://dx.doi.org/10.24272/j.issn.2095-8137.2018.013 |
work_keys_str_mv | AT guoweina animalmodelsforthestudyofhepatitisbvirusinfection AT zhubin animalmodelsforthestudyofhepatitisbvirusinfection AT ailing animalmodelsforthestudyofhepatitisbvirusinfection AT yangdongliang animalmodelsforthestudyofhepatitisbvirusinfection AT wangbaoju animalmodelsforthestudyofhepatitisbvirusinfection |