Cargando…

Animal models for the study of hepatitis B virus infection

Even with an effective vaccine, an estimated 240 million people are chronically infected with hepatitis B virus (HBV) worldwide. Current antiviral therapies, including interferon and nucleot(s)ide analogues, rarely cure chronic hepatitis B. Animal models are very crucial for understanding the pathog...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Wei-Na, Zhu, Bin, Ai, Ling, Yang, Dong-Liang, Wang, Bao-Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Science Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869238/
https://www.ncbi.nlm.nih.gov/pubmed/29511142
http://dx.doi.org/10.24272/j.issn.2095-8137.2018.013
_version_ 1783309247702892544
author Guo, Wei-Na
Zhu, Bin
Ai, Ling
Yang, Dong-Liang
Wang, Bao-Ju
author_facet Guo, Wei-Na
Zhu, Bin
Ai, Ling
Yang, Dong-Liang
Wang, Bao-Ju
author_sort Guo, Wei-Na
collection PubMed
description Even with an effective vaccine, an estimated 240 million people are chronically infected with hepatitis B virus (HBV) worldwide. Current antiviral therapies, including interferon and nucleot(s)ide analogues, rarely cure chronic hepatitis B. Animal models are very crucial for understanding the pathogenesis of chronic hepatitis B and developing new therapeutic drugs or strategies. HBV can only infect humans and chimpanzees, with the use of chimpanzees in HBV research strongly restricted. Thus, most advances in HBV research have been gained using mouse models with HBV replication or infection or models with HBV-related hepadnaviral infection. This review summarizes the animal models currently available for the study of HBV infection.
format Online
Article
Text
id pubmed-5869238
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Science Press
record_format MEDLINE/PubMed
spelling pubmed-58692382018-04-12 Animal models for the study of hepatitis B virus infection Guo, Wei-Na Zhu, Bin Ai, Ling Yang, Dong-Liang Wang, Bao-Ju Zool Res Review Even with an effective vaccine, an estimated 240 million people are chronically infected with hepatitis B virus (HBV) worldwide. Current antiviral therapies, including interferon and nucleot(s)ide analogues, rarely cure chronic hepatitis B. Animal models are very crucial for understanding the pathogenesis of chronic hepatitis B and developing new therapeutic drugs or strategies. HBV can only infect humans and chimpanzees, with the use of chimpanzees in HBV research strongly restricted. Thus, most advances in HBV research have been gained using mouse models with HBV replication or infection or models with HBV-related hepadnaviral infection. This review summarizes the animal models currently available for the study of HBV infection. Science Press 2018-02-09 2018-01-18 /pmc/articles/PMC5869238/ /pubmed/29511142 http://dx.doi.org/10.24272/j.issn.2095-8137.2018.013 Text en © 2018. Editorial Office of Zoological Research, Kunming Institute of Zoology, Chinese Academy of Sciences http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Guo, Wei-Na
Zhu, Bin
Ai, Ling
Yang, Dong-Liang
Wang, Bao-Ju
Animal models for the study of hepatitis B virus infection
title Animal models for the study of hepatitis B virus infection
title_full Animal models for the study of hepatitis B virus infection
title_fullStr Animal models for the study of hepatitis B virus infection
title_full_unstemmed Animal models for the study of hepatitis B virus infection
title_short Animal models for the study of hepatitis B virus infection
title_sort animal models for the study of hepatitis b virus infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869238/
https://www.ncbi.nlm.nih.gov/pubmed/29511142
http://dx.doi.org/10.24272/j.issn.2095-8137.2018.013
work_keys_str_mv AT guoweina animalmodelsforthestudyofhepatitisbvirusinfection
AT zhubin animalmodelsforthestudyofhepatitisbvirusinfection
AT ailing animalmodelsforthestudyofhepatitisbvirusinfection
AT yangdongliang animalmodelsforthestudyofhepatitisbvirusinfection
AT wangbaoju animalmodelsforthestudyofhepatitisbvirusinfection