Cargando…

Ethics of treatment interruption trials in HIV cure research: addressing the conundrum of risk/benefit assessment

Though antiretroviral therapy is the standard of care for people living with HIV, its treatment limitations, burdens, stigma and costs lead to continued interest in HIV cure research. Early-phase cure trials, particularly those that include analytic treatment interruption (ATI), involve uncertain an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Henderson, Gail E, Peay, Holly L, Kroon, Eugene, Cadigan, Rosemary Jean, Meagher, Karen, Jupimai, Thidarat, Gilbertson, Adam, Fisher, Jill, Ormsby, Nuchanart Q, Chomchey, Nitiya, Phanuphak, Nittaya, Ananworanich, Jintanat, Rennie, Stuart
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2018
Materias:	Research Ethics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869463/ https://www.ncbi.nlm.nih.gov/pubmed/29127137 http://dx.doi.org/10.1136/medethics-2017-104433

Ejemplares similares

Going off antiretroviral treatment in a closely monitored HIV “cure” trial: longitudinal assessments of acutely diagnosed trial participants and decliners
por: Henderson, Gail E, et al.
Publicado: (2019)

Decision making for invasive and non-invasive optional procedures within an acute HIV research cohort in Bangkok
por: Isaacson, Sinéad, et al.
Publicado: (2022)

Corrigendum to ‘Decision making for invasive and non-invasive optional procedures within an acute HIV research cohort in Bangkok,’ [Contemporary Clinical Trials Communication (2023)101054]
por: Isaacson, Sinéad, et al.
Publicado: (2023)

Recommendations from Thai stakeholders about protecting HIV remission (‘cure’) trial participants: report from a participatory workshop
por: Peay, Holly L, et al.
Publicado: (2020)

Parallel but connected: Nuances of conducting behavioral and social science research alongside ethically challenging HIV remission trials
por: Henderson, Gail E., et al.
Publicado: (2020)

Interrupting antiretroviral treatment in HIV cure research: scientific and ethical considerations
por: Garner, Samual A, et al.
Publicado: (2017)

Brief Report: Safety of Frequent Blood Sampling in Research Participants in an Acute HIV Infection Cohort in Thailand
por: Sacdalan, Carlo, et al.
Publicado: (2017)

HIV serostatus disclosure is not associated with safer sexual behavior among HIV-positive men who have sex with men (MSM) and their partners at risk for infection in Bangkok, Thailand
por: Edwards-Jackson, Nneka, et al.
Publicado: (2012)

Factors associated with intention to take non-occupational HIV post-exposure prophylaxis among Thai men who have sex with men
por: Chomchey, Nitiya, et al.
Publicado: (2017)

Leveraging early HIV diagnosis and treatment in Thailand to conduct HIV cure research
por: Muccini, Camilla, et al.
Publicado: (2019)

Anogenital HIV RNA in Thai men who have sex with men in Bangkok during acute HIV infection and after randomization to standard vs. intensified antiretroviral regimens
por: Phanuphak, Nittaya, et al.
Publicado: (2015)

Low incidence of HIV infection in an anonymous HIV counselling and testing clinic cohort in Bangkok, Thailand despite high HIV prevalence and self-report of high-risk behaviour
por: Phanuphak, Nittaya, et al.
Publicado: (2015)

Switch to dolutegravir is well tolerated in Thais with HIV infection
por: Goh, Orlanda Q, et al.
Publicado: (2019)

HIV remission trial investigators’ attitudes towards risk and risk mitigation in trials that include treatment interruption
por: Okumu, Eunice Akinyi, et al.
Publicado: (2023)

Markers of HIV reservoir size and immune activation after treatment in acute HIV infection with and without raltegravir and maraviroc intensification
por: Ananworanich, Jintanat, et al.
Publicado: (2015)

Preferential Infection of α4β7(+) Memory CD4(+) T Cells During Early Acute Human Immunodeficiency Virus Type 1 Infection
por: Tokarev, Andrey, et al.
Publicado: (2020)

Corrigendum to “HIV remission trial investigators’ attitudes towards risk and risk mitigation in trials that include treatment interruption” [J Virus Erad 9 (2) (June 2023) 100331]
por: Okumu, Eunice Akinyi, et al.
Publicado: (2023)

Initiation of antiretroviral therapy before detection of colonic infiltration by HIV reduces viral reservoirs, inflammation and immune activation
por: Crowell, Trevor A, et al.
Publicado: (2016)

Acute HIV infection detection and immediate treatment estimated to reduce transmission by 89% among men who have sex with men in Bangkok
por: Kroon, Eugène D.M.B., et al.
Publicado: (2017)

Acute tubular nephropathy in a patient with acute HIV infection: review of the literature
por: Ananworanich, Jintanat, et al.
Publicado: (2014)

A randomized trial of vorinostat with treatment interruption after initiating antiretroviral therapy during acute HIV-1 infection
por: Kroon, Eugène D.M.B., et al.
Publicado: (2020)

Rapid HIV RNA rebound after antiretroviral treatment interruption in persons durably suppressed in Fiebig I acute HIV infection
por: Colby, Donn, et al.
Publicado: (2018)

Distal leg epidermal nerve fiber density as a surrogate marker of HIV-associated sensory neuropathy risk: risk factors and change following initial antiretroviral therapy
por: Shikuma, Cecilia M., et al.
Publicado: (2015)

Implementation of an online HIV prevention and treatment cascade in Thai men who have sex with men and transgender women using Adam's Love Electronic Health Record system
por: Anand, Tarandeep, et al.
Publicado: (2017)

An adapted instrument to assess informed consent comprehension among youth and parents in rural western Kenya: a validation study
por: Afolabi, Muhammed Olanrewaju, et al.
Publicado: (2018)

HIV cure research: a formidable challenge
por: Ananworanich, Jintanat, et al.
Publicado: (2015)

Innovative strategies using communications technologies to engage gay men and other men who have sex with men into early HIV testing and treatment in Thailand
por: Anand, Tarandeep, et al.
Publicado: (2015)

Impact of Multi-Targeted Antiretroviral Treatment on Gut T Cell Depletion and HIV Reservoir Seeding during Acute HIV Infection
por: Ananworanich, Jintanat, et al.
Publicado: (2012)

Molecular epidemiology of a primarily MSM acute HIV‐1 cohort in Bangkok, Thailand and connections within networks of transmission in Asia
por: Chang, David, et al.
Publicado: (2018)

Declining trend in transmitted drug resistance detected in a prospective cohort study of acute HIV infection in Bangkok, Thailand
por: Colby, Donn J, et al.
Publicado: (2016)

Community participation in HIV cure research: perspectives from Thailand
por: Phanuphak, Nittaya, et al.
Publicado: (2015)

Supersensitive Viral Load Assay in Predicting CD4-Guided Treatment Failure
por: Langford, Simone, et al.
Publicado: (2008)

Penile transplantation as an appropriate response to botched traditional circumcisions in South Africa: an argument against
por: Moodley, Keymanthri, et al.
Publicado: (2018)

A novel acute HIV infection staging system based on 4(th) generation immunoassay
por: Ananworanich, Jintanat, et al.
Publicado: (2013)

How Much HIV is Alive? The Challenge of Measuring Replication Competent HIV for HIV Cure Research
por: Ananworanich, Jintanat, et al.
Publicado: (2015)

How Biomedical HIV Prevention Trials Incorporate Behavioral and Social Sciences Research: A Typology of Approaches
por: Corneli, Amy, et al.
Publicado: (2018)

Paradoxically Greater Persistence of HIV RNA-Positive Cells in Lymphoid Tissue When ART Is Initiated in the Earliest Stage of Infection
por: Kroon, Eugène, et al.
Publicado: (2022)

A novel Online-to-Offline (O2O) model for pre-exposure prophylaxis and HIV testing scale up
por: Anand, Tarandeep, et al.
Publicado: (2017)

Comparing Interferon-Gamma Release Assays to Tuberculin Skin Test in Thai Children with Tuberculosis Exposure
por: Tieu, Hong-Van, et al.
Publicado: (2014)

Is there gender bias in HIV cure research? A case study of female representation at the 2015 HIV Persistence Workshop
por: Johnston, Rowena, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_jr7pb2972ngs273ta5ieala6a0