Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory

The increasing frequency of monkeypox virus infections, new outbreaks of other zoonotic orthopoxviruses and concern about the re-emergence of smallpox have prompted research into developing antiviral drugs and better vaccines against these viruses. This article considers the genetic engineering of v...

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Detalles Bibliográficos
Autores principales: Albarnaz, Jonas D., Torres, Alice A., Smith, Geoffrey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869494/
https://www.ncbi.nlm.nih.gov/pubmed/29495547
http://dx.doi.org/10.3390/v10030101
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author Albarnaz, Jonas D.
Torres, Alice A.
Smith, Geoffrey L.
author_facet Albarnaz, Jonas D.
Torres, Alice A.
Smith, Geoffrey L.
author_sort Albarnaz, Jonas D.
collection PubMed
description The increasing frequency of monkeypox virus infections, new outbreaks of other zoonotic orthopoxviruses and concern about the re-emergence of smallpox have prompted research into developing antiviral drugs and better vaccines against these viruses. This article considers the genetic engineering of vaccinia virus (VACV) to enhance vaccine immunogenicity and safety. The virulence, immunogenicity and protective efficacy of VACV strains engineered to lack specific immunomodulatory or host range proteins are described. The ultimate goal is to develop safer and more immunogenic VACV vaccines that induce long-lasting immunological memory.
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spelling pubmed-58694942018-03-28 Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory Albarnaz, Jonas D. Torres, Alice A. Smith, Geoffrey L. Viruses Review The increasing frequency of monkeypox virus infections, new outbreaks of other zoonotic orthopoxviruses and concern about the re-emergence of smallpox have prompted research into developing antiviral drugs and better vaccines against these viruses. This article considers the genetic engineering of vaccinia virus (VACV) to enhance vaccine immunogenicity and safety. The virulence, immunogenicity and protective efficacy of VACV strains engineered to lack specific immunomodulatory or host range proteins are described. The ultimate goal is to develop safer and more immunogenic VACV vaccines that induce long-lasting immunological memory. MDPI 2018-02-28 /pmc/articles/PMC5869494/ /pubmed/29495547 http://dx.doi.org/10.3390/v10030101 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Albarnaz, Jonas D.
Torres, Alice A.
Smith, Geoffrey L.
Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory
title Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory
title_full Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory
title_fullStr Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory
title_full_unstemmed Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory
title_short Modulating Vaccinia Virus Immunomodulators to Improve Immunological Memory
title_sort modulating vaccinia virus immunomodulators to improve immunological memory
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869494/
https://www.ncbi.nlm.nih.gov/pubmed/29495547
http://dx.doi.org/10.3390/v10030101
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