Concomitant Non-Small Cell Lung Cancer and Hairy Cell Leukemia in a Patient Harboring BRAF-V600E Mutation in Both Tissues: A Case Report

The BRAF-V600E mutation has been established as a signature alteration occurring almost universally in hairy cell leukemia. Moreover, it can be detected in a small percentage of patients with non-small cell lung cancer. We report the case of a patient with a metastatic BRAF-V600E-mutated lung adenoc...

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Autores principales: Mitsogianni, Maria, Mitsimponas, Nikolaos, Crespo, Felipe, Hartmann, Karl Axel, Klosterhalfen, Bernd, Haase, Sabine, Giagounidis, Aristoteles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869534/
https://www.ncbi.nlm.nih.gov/pubmed/29606948
http://dx.doi.org/10.1159/000486640
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author Mitsogianni, Maria
Mitsimponas, Nikolaos
Crespo, Felipe
Hartmann, Karl Axel
Klosterhalfen, Bernd
Haase, Sabine
Giagounidis, Aristoteles
author_facet Mitsogianni, Maria
Mitsimponas, Nikolaos
Crespo, Felipe
Hartmann, Karl Axel
Klosterhalfen, Bernd
Haase, Sabine
Giagounidis, Aristoteles
author_sort Mitsogianni, Maria
collection PubMed
description The BRAF-V600E mutation has been established as a signature alteration occurring almost universally in hairy cell leukemia. Moreover, it can be detected in a small percentage of patients with non-small cell lung cancer. We report the case of a patient with a metastatic BRAF-V600E-mutated lung adenocarcinoma suffering from concomitant hairy cell leukemia. The identification of an identical BRAF mutation in both malignancies raises physiopathological considerations and might offer unique therapeutic strategies for this group of patients.
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spelling pubmed-58695342018-03-30 Concomitant Non-Small Cell Lung Cancer and Hairy Cell Leukemia in a Patient Harboring BRAF-V600E Mutation in Both Tissues: A Case Report Mitsogianni, Maria Mitsimponas, Nikolaos Crespo, Felipe Hartmann, Karl Axel Klosterhalfen, Bernd Haase, Sabine Giagounidis, Aristoteles Case Rep Oncol Case Report The BRAF-V600E mutation has been established as a signature alteration occurring almost universally in hairy cell leukemia. Moreover, it can be detected in a small percentage of patients with non-small cell lung cancer. We report the case of a patient with a metastatic BRAF-V600E-mutated lung adenocarcinoma suffering from concomitant hairy cell leukemia. The identification of an identical BRAF mutation in both malignancies raises physiopathological considerations and might offer unique therapeutic strategies for this group of patients. S. Karger AG 2018-02-14 /pmc/articles/PMC5869534/ /pubmed/29606948 http://dx.doi.org/10.1159/000486640 Text en Copyright © 2018 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Mitsogianni, Maria
Mitsimponas, Nikolaos
Crespo, Felipe
Hartmann, Karl Axel
Klosterhalfen, Bernd
Haase, Sabine
Giagounidis, Aristoteles
Concomitant Non-Small Cell Lung Cancer and Hairy Cell Leukemia in a Patient Harboring BRAF-V600E Mutation in Both Tissues: A Case Report
title Concomitant Non-Small Cell Lung Cancer and Hairy Cell Leukemia in a Patient Harboring BRAF-V600E Mutation in Both Tissues: A Case Report
title_full Concomitant Non-Small Cell Lung Cancer and Hairy Cell Leukemia in a Patient Harboring BRAF-V600E Mutation in Both Tissues: A Case Report
title_fullStr Concomitant Non-Small Cell Lung Cancer and Hairy Cell Leukemia in a Patient Harboring BRAF-V600E Mutation in Both Tissues: A Case Report
title_full_unstemmed Concomitant Non-Small Cell Lung Cancer and Hairy Cell Leukemia in a Patient Harboring BRAF-V600E Mutation in Both Tissues: A Case Report
title_short Concomitant Non-Small Cell Lung Cancer and Hairy Cell Leukemia in a Patient Harboring BRAF-V600E Mutation in Both Tissues: A Case Report
title_sort concomitant non-small cell lung cancer and hairy cell leukemia in a patient harboring braf-v600e mutation in both tissues: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869534/
https://www.ncbi.nlm.nih.gov/pubmed/29606948
http://dx.doi.org/10.1159/000486640
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