Drugs Being Eliminated via the Same Pathway Will Not Always Require Similar Pediatric Dose Adjustments

For scaling drug plasma clearance (CLp) from adults to children, extrapolations of population pharmacokinetic (PopPK) covariate models between drugs sharing an elimination pathway have enabled accelerated development of pediatric models and dosing recommendations. This study aims at identifying cond...

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Detalles Bibliográficos
Autores principales: Calvier, Elisa A. M., Krekels, Elke H. J., Yu, Huixin, Välitalo, Pyry A. J., Johnson, Trevor N., Rostami‐Hodjegan, Amin, Tibboel, Dick, van der Graaf, Piet H., Danhof, Meindert, Knibbe, Catherijne A. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869561/
https://www.ncbi.nlm.nih.gov/pubmed/29399979
http://dx.doi.org/10.1002/psp4.12273

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869561/
https://www.ncbi.nlm.nih.gov/pubmed/29399979
http://dx.doi.org/10.1002/psp4.12273

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