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Influence of optic disc-fovea distance on macular thickness measurements with OCT in healthy myopic eyes

Assessment of macular thickness is important in the evaluation of various eye diseases. This study aimed to determine the influence of the optic disc-fovea distance (DFD) on macular thickness in myopic eyes. We determined the DFD and the macular thickness in 138 eyes from 138 healthy myopic subjects...

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Autores principales: Qiu, Kunliang, Wang, Geng, Zhang, Riping, Lu, Xuehui, Zhang, Mingzhi, Jansonius, Nomdo M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869586/
https://www.ncbi.nlm.nih.gov/pubmed/29588514
http://dx.doi.org/10.1038/s41598-018-23479-z
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author Qiu, Kunliang
Wang, Geng
Zhang, Riping
Lu, Xuehui
Zhang, Mingzhi
Jansonius, Nomdo M.
author_facet Qiu, Kunliang
Wang, Geng
Zhang, Riping
Lu, Xuehui
Zhang, Mingzhi
Jansonius, Nomdo M.
author_sort Qiu, Kunliang
collection PubMed
description Assessment of macular thickness is important in the evaluation of various eye diseases. This study aimed to determine the influence of the optic disc-fovea distance (DFD) on macular thickness in myopic eyes. We determined the DFD and the macular thickness in 138 eyes from 138 healthy myopic subjects using the Cirrus HD-OCT. Correlation analysis and multiple linear regression were performed to determine the influence of DFD, axial length, disc area, and β-PPA on macular thickness. To further remove the confounding effect of ocular magnification on the DFD and OCT scan area, a subgroup analysis was performed in eyes with a limited axial length range (24–25 mm). DFD was significantly correlated with both regional (central, inner, and outer ETDRS subfields) and overall average macular thickness at a Bonferroni corrected P value of 0.004 (r ranging from −0.27 to −0.47), except for the temporal outer (r = −0.15, P = 0.089) and inferior outer (r = −0.22, P = 0.011) macular thickness. In the multivariable analysis, DFD was significantly associated with the average inner and outer macular thickness, the central subfield thickness, and the overall macular thickness (all P < 0.001), independent of ocular magnification and other covariates. Our findings indicate that eyes with a greater DFD have a lower macular thickness.
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spelling pubmed-58695862018-04-02 Influence of optic disc-fovea distance on macular thickness measurements with OCT in healthy myopic eyes Qiu, Kunliang Wang, Geng Zhang, Riping Lu, Xuehui Zhang, Mingzhi Jansonius, Nomdo M. Sci Rep Article Assessment of macular thickness is important in the evaluation of various eye diseases. This study aimed to determine the influence of the optic disc-fovea distance (DFD) on macular thickness in myopic eyes. We determined the DFD and the macular thickness in 138 eyes from 138 healthy myopic subjects using the Cirrus HD-OCT. Correlation analysis and multiple linear regression were performed to determine the influence of DFD, axial length, disc area, and β-PPA on macular thickness. To further remove the confounding effect of ocular magnification on the DFD and OCT scan area, a subgroup analysis was performed in eyes with a limited axial length range (24–25 mm). DFD was significantly correlated with both regional (central, inner, and outer ETDRS subfields) and overall average macular thickness at a Bonferroni corrected P value of 0.004 (r ranging from −0.27 to −0.47), except for the temporal outer (r = −0.15, P = 0.089) and inferior outer (r = −0.22, P = 0.011) macular thickness. In the multivariable analysis, DFD was significantly associated with the average inner and outer macular thickness, the central subfield thickness, and the overall macular thickness (all P < 0.001), independent of ocular magnification and other covariates. Our findings indicate that eyes with a greater DFD have a lower macular thickness. Nature Publishing Group UK 2018-03-27 /pmc/articles/PMC5869586/ /pubmed/29588514 http://dx.doi.org/10.1038/s41598-018-23479-z Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Qiu, Kunliang
Wang, Geng
Zhang, Riping
Lu, Xuehui
Zhang, Mingzhi
Jansonius, Nomdo M.
Influence of optic disc-fovea distance on macular thickness measurements with OCT in healthy myopic eyes
title Influence of optic disc-fovea distance on macular thickness measurements with OCT in healthy myopic eyes
title_full Influence of optic disc-fovea distance on macular thickness measurements with OCT in healthy myopic eyes
title_fullStr Influence of optic disc-fovea distance on macular thickness measurements with OCT in healthy myopic eyes
title_full_unstemmed Influence of optic disc-fovea distance on macular thickness measurements with OCT in healthy myopic eyes
title_short Influence of optic disc-fovea distance on macular thickness measurements with OCT in healthy myopic eyes
title_sort influence of optic disc-fovea distance on macular thickness measurements with oct in healthy myopic eyes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869586/
https://www.ncbi.nlm.nih.gov/pubmed/29588514
http://dx.doi.org/10.1038/s41598-018-23479-z
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