Extensive molecular tinkering in the evolution of the membrane attachment mode of the Rheb GTPase

Rheb is a conserved and widespread Ras-like GTPase involved in cell growth regulation mediated by the (m)TORC1 kinase complex and implicated in tumourigenesis in humans. Rheb function depends on its association with membranes via prenylated C-terminus, a mechanism shared with many other eukaryotic G...

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Detalles Bibliográficos
Autores principales: Záhonová, Kristína, Petrželková, Romana, Valach, Matus, Yazaki, Euki, Tikhonenkov, Denis V., Butenko, Anzhelika, Janouškovec, Jan, Hrdá, Štěpánka, Klimeš, Vladimír, Burger, Gertraud, Inagaki, Yuji, Keeling, Patrick J., Hampl, Vladimír, Flegontov, Pavel, Yurchenko, Vyacheslav, Eliáš, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869587/
https://www.ncbi.nlm.nih.gov/pubmed/29588502
http://dx.doi.org/10.1038/s41598-018-23575-0

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