Cargando…

Ras hyperactivation versus overexpression: Lessons from Ras dynamics in Candida albicans

Ras signaling in response to environmental cues is critical for cellular morphogenesis in eukaryotes. This signaling is tightly regulated and its activation involves multiple players. Sometimes Ras signaling may be hyperactivated. In C. albicans, a human pathogenic fungus, we demonstrate that dynami...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pratyusha, Vavilala A., Victoria, Guiliana Soraya, Khan, Mohammad Firoz, Haokip, Dominic T., Yadav, Bhawna, Pal, Nibedita, Sethi, Subhash Chandra, Jain, Priyanka, Singh, Sneh Lata, Sen, Sobhan, Komath, Sneha Sudha
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869725/ https://www.ncbi.nlm.nih.gov/pubmed/29588468 http://dx.doi.org/10.1038/s41598-018-23187-8

Ejemplares similares

Author Correction: Ras hyperactivation versus overexpression: Lessons from Ras dynamics in Candida albicans
por: Pratyusha, Vavilala A., et al.
Publicado: (2019)

Modulation of azole sensitivity and filamentation by GPI15, encoding a subunit of the first GPI biosynthetic enzyme, in Candida albicans
por: Jain, Priyanka, et al.
Publicado: (2019)

The GPI Anchor Signal Sequence Dictates the Folding and Functionality of the Als5 Adhesin from Candida albicans
por: Ahmad, Mohammad Faiz, et al.
Publicado: (2012)

EZH2 inactivation in RAS-driven myeloid neoplasms hyperactivates RAS-signaling and increases MEK inhibitor sensitivity
por: Berg, Johannes Lorenz, et al.
Publicado: (2021)

The Significance of Lipids to Biofilm Formation in Candida albicans: An Emerging Perspective
por: Alim, Darakshan, et al.
Publicado: (2018)

Mannich base limits Candida albicans virulence by inactivating Ras-cAMP-PKA pathway
por: Rajasekharan, Satish Kumar, et al.
Publicado: (2018)

Onco-immunomodulatory properties of pharmacological interference with RAS-RAF-MEK-ERK pathway hyperactivation
por: Avery, Thomas Yul, et al.
Publicado: (2022)

Mitochondrial proline catabolism activates Ras1/cAMP/PKA-induced filamentation in Candida albicans
por: Silao, Fitz Gerald S., et al.
Publicado: (2019)

Nf1 Loss and Ras Hyperactivation in Oligodendrocytes Induce NOS-Driven Defects in Myelin and Vasculature
por: Mayes, Debra A., et al.
Publicado: (2013)

Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells
por: Unni, Arun M, et al.
Publicado: (2018)

Sef1-Regulated Iron Regulon Responds to Mitochondria-Dependent Iron–Sulfur Cluster Biosynthesis in Candida albicans
por: Ror, Shivani, et al.
Publicado: (2019)

The Cdc25 and Ras1 Proteins of Candida albicans Influence Epithelial Toxicity in a Niche-Specific Way
por: Wijnants, Stefanie, et al.
Publicado: (2023)

Shikonin Inhibits Candida albicans Biofilms via the Ras1-cAMP-Efg1 Signalling Pathway
por: Pang, Chong, et al.
Publicado: (2023)

Oncogenic Ras mutant causes the hyperactivation of NF‐κB via acceleration of its transcriptional activation
por: Tago, Kenji, et al.
Publicado: (2019)

Hyperactivated RAGE in Comorbidities as a Risk Factor for Severe COVID-19—The Role of RAGE-RAS Crosstalk
por: Chiappalupi, Sara, et al.
Publicado: (2021)

Sho1p Connects Glycolysis to Ras1-cAMP Signaling and Is Required for Microcolony Formation in Candida albicans
por: Kumar, Rohitashw, et al.
Publicado: (2020)

Pathogen-specific structural features of Candida albicans Ras1 activation complex: uncovering new antifungal drug targets
por: Manso, José A., et al.
Publicado: (2023)

Development of Carbazole Derivatives Compounds against Candida albicans: Candidates to Prevent Hyphal Formation via the Ras1-MAPK Pathway
por: Park, Young-Kwang, et al.
Publicado: (2021)

Dynamic regulation of RAS and RAS signaling
por: Kolch, Walter, et al.
Publicado: (2023)

Adaptation to Endoplasmic Reticulum Stress in Candida albicans Relies on the Activity of the Hog1 Mitogen-Activated Protein Kinase
por: Husain, Farha, et al.
Publicado: (2022)

Non-Toxic and Ultra-Small Biosilver Nanoclusters Trigger Apoptotic Cell Death in Fluconazole-Resistant Candida albicans via Ras Signaling
por: Prateeksha,, et al.
Publicado: (2019)

RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome–associated cardiac hypertrophy
por: Cuevas-Navarro, Antonio, et al.
Publicado: (2023)

The protein kinase Ire1 impacts pathogenicity of Candida albicans by regulating homeostatic adaptation to endoplasmic reticulum stress
por: Sircaik, Shabnam, et al.
Publicado: (2021)

Lipid Profiles of RAS Nanoclusters Regulate RAS Function
por: Zhou, Yong, et al.
Publicado: (2021)

The Role of Wild-Type RAS in Oncogenic RAS Transformation
por: Sheffels, Erin, et al.
Publicado: (2021)

Oligomer β-amyloid Induces Hyperactivation of Ras to Impede NMDA Receptor-Dependent Long-Term Potentiation in Hippocampal CA1 of Mice
por: Wang, Ya, et al.
Publicado: (2020)

Ras on the inside
por: LeBrasseur, Nicole
Publicado: (2002)

Escorting Ras
por: Zheng, Ze-Yi, et al.
Publicado: (2012)

Local RAS
por: Leung, Po Sing
Publicado: (2010)

RAS Mutations and Oncogenesis: Not all RAS Mutations are Created Equally
por: Miller, Mark Steven, et al.
Publicado: (2012)

Mechanisms of Ras Membrane Organization and Signaling: Ras Rocks Again
por: Abankwa, Daniel, et al.
Publicado: (2020)

RAS Dimers: The Novice Couple at the RAS-ERK Pathway Ball
por: Herrero, Ana, et al.
Publicado: (2021)

Sodium New Houttuyfonate Inhibits Candida albicans Biofilm Formation by Inhibiting the Ras1-cAMP-Efg1 Pathway Revealed by RNA-seq
por: Wu, Jiadi, et al.
Publicado: (2020)

The NF2 tumor suppressor merlin interacts with Ras and RasGAP, which may modulate Ras signaling
por: Cui, Yan, et al.
Publicado: (2019)

Graded inhibition of oncogenic Ras-signaling by multivalent Ras-binding domains
por: Augsten, Martin, et al.
Publicado: (2014)

Ras protein abundance correlates with Ras isoform mutation patterns in cancer
por: Hood, Fiona E., et al.
Publicado: (2023)

TNF-dependent hyperactivation of RIPK1-dependent cytotoxic signaling during embryogenesis and inflammation
por: Mocarski, Edward S., et al.
Publicado: (2021)

Tumor RAS Gene Expression Levels Are Influenced by the Mutational Status of RAS Genes and Both Upstream and Downstream RAS Pathway Genes
por: Stephens, Robert M, et al.
Publicado: (2017)

Killer K-Ras
por: Powell, Kendall
Publicado: (2006)

Ras in epidermal proliferation
por: Drosten, Matthias, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_su8o5crl49chdbfs96ku7qq7dv